Tags

Type your tag names separated by a space and hit enter

Penetration of oligonucleotides into mouse organism through mucosa and skin.
FEBS Lett 1993; 327(3):271-4FL

Abstract

Benzylamide 5'-32P-oligonucleotide derivatives were shown to penetrate into mice organism when administered by various routes; intranasally, per os, intravaginally and per rectum. In all cases, the compounds are rapidly accumulated in blood and guts. Analysis of the radioactive material from blood and pancreas revealed intact oligonucleotides. Although concentrations of oligonucleotides in tissues differ considerably by the various methods of administration, the efficiency of delivery is sufficient to consider all the routes as being of therapeutic value. Dose effect on the efficiency of oligonucleotide penetration into mice suggests the transport to be a saturable process. Application of an oligonucleotide lotion on mice ear helices results in reproducible accumulation of radioactivity in the animal tissues. Effectiveness of oligonucleotide delivery into mouse through skin can be improved by using electrophoretic procedure.

Authors+Show Affiliations

Institute of Bioorganic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8348953

Citation

Vlassov, V V., et al. "Penetration of Oligonucleotides Into Mouse Organism Through Mucosa and Skin." FEBS Letters, vol. 327, no. 3, 1993, pp. 271-4.
Vlassov VV, Karamyshev VN, Yakubov LA. Penetration of oligonucleotides into mouse organism through mucosa and skin. FEBS Lett. 1993;327(3):271-4.
Vlassov, V. V., Karamyshev, V. N., & Yakubov, L. A. (1993). Penetration of oligonucleotides into mouse organism through mucosa and skin. FEBS Letters, 327(3), pp. 271-4.
Vlassov VV, Karamyshev VN, Yakubov LA. Penetration of Oligonucleotides Into Mouse Organism Through Mucosa and Skin. FEBS Lett. 1993 Aug 2;327(3):271-4. PubMed PMID: 8348953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Penetration of oligonucleotides into mouse organism through mucosa and skin. AU - Vlassov,V V, AU - Karamyshev,V N, AU - Yakubov,L A, PY - 1993/8/2/pubmed PY - 1993/8/2/medline PY - 1993/8/2/entrez SP - 271 EP - 4 JF - FEBS letters JO - FEBS Lett. VL - 327 IS - 3 N2 - Benzylamide 5'-32P-oligonucleotide derivatives were shown to penetrate into mice organism when administered by various routes; intranasally, per os, intravaginally and per rectum. In all cases, the compounds are rapidly accumulated in blood and guts. Analysis of the radioactive material from blood and pancreas revealed intact oligonucleotides. Although concentrations of oligonucleotides in tissues differ considerably by the various methods of administration, the efficiency of delivery is sufficient to consider all the routes as being of therapeutic value. Dose effect on the efficiency of oligonucleotide penetration into mice suggests the transport to be a saturable process. Application of an oligonucleotide lotion on mice ear helices results in reproducible accumulation of radioactivity in the animal tissues. Effectiveness of oligonucleotide delivery into mouse through skin can be improved by using electrophoretic procedure. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/8348953/Penetration_of_oligonucleotides_into_mouse_organism_through_mucosa_and_skin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)81002-H DB - PRIME DP - Unbound Medicine ER -