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Impaired motor axon regeneration in the C57BL/Ola mouse.
J Comp Neurol. 1993 Jul 15; 333(3):449-54.JC

Abstract

The delayed Wallerian degeneration which occurs in the C57BL/Ola mouse is associated with impaired motor axon regeneration. Following sciatic nerve crush, recovery of the sciatic functional index was delayed and incomplete when compared with recovery in C57BL/6J mice. After facial nerve crush, recovery of whisker movement in Ola mice was also delayed, and there was a prolonged period of partial recovery, not seen in 6J mice. Regeneration rate of the motor axons was measured by the axonal transport technique in sciatic nerve and was approximately 0.7 mm/d for Ola mice, and 4.0 mm/d for 6J mice. Combining these results from our previous work, we conclude that regeneration of both sensory and motor axons is impaired when Wallerian degeneration does not follow its usual time course after injury.

Authors+Show Affiliations

Department of Physiology, Queen's University, Kingston, Ontario, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8349851

Citation

Chen, S, and M A. Bisby. "Impaired Motor Axon Regeneration in the C57BL/Ola Mouse." The Journal of Comparative Neurology, vol. 333, no. 3, 1993, pp. 449-54.
Chen S, Bisby MA. Impaired motor axon regeneration in the C57BL/Ola mouse. J Comp Neurol. 1993;333(3):449-54.
Chen, S., & Bisby, M. A. (1993). Impaired motor axon regeneration in the C57BL/Ola mouse. The Journal of Comparative Neurology, 333(3), 449-54.
Chen S, Bisby MA. Impaired Motor Axon Regeneration in the C57BL/Ola Mouse. J Comp Neurol. 1993 Jul 15;333(3):449-54. PubMed PMID: 8349851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired motor axon regeneration in the C57BL/Ola mouse. AU - Chen,S, AU - Bisby,M A, PY - 1993/7/15/pubmed PY - 1993/7/15/medline PY - 1993/7/15/entrez SP - 449 EP - 54 JF - The Journal of comparative neurology JO - J Comp Neurol VL - 333 IS - 3 N2 - The delayed Wallerian degeneration which occurs in the C57BL/Ola mouse is associated with impaired motor axon regeneration. Following sciatic nerve crush, recovery of the sciatic functional index was delayed and incomplete when compared with recovery in C57BL/6J mice. After facial nerve crush, recovery of whisker movement in Ola mice was also delayed, and there was a prolonged period of partial recovery, not seen in 6J mice. Regeneration rate of the motor axons was measured by the axonal transport technique in sciatic nerve and was approximately 0.7 mm/d for Ola mice, and 4.0 mm/d for 6J mice. Combining these results from our previous work, we conclude that regeneration of both sensory and motor axons is impaired when Wallerian degeneration does not follow its usual time course after injury. SN - 0021-9967 UR - https://www.unboundmedicine.com/medline/citation/8349851/Impaired_motor_axon_regeneration_in_the_C57BL/Ola_mouse_ DB - PRIME DP - Unbound Medicine ER -