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[Effects of furyl-dihydropyridine on action potential ventricular myocardium of rabbit in vivo and isolated guinea pig left atrium in vitro].
Zhongguo Yao Li Xue Bao. 1993 Mar; 14(2):164-7.ZY

Abstract

Effects of furyl-dihydropyridine (FDP) on action potential of rabbit ventricular myocardium in vivo were observed with floating microelectrode technique. FDP 0.5 mg.kg-1 i.v. increased APD30 from 104 +/- 7 to 127 +/- 7 ms, APD90 from 146 +/- 10 to 177 +/- 9 ms (P < 0.01, n = 7), decreased the heart rate from 230 +/- 18 to 203 +/- 20 bpm (P < 0.05). Nifedipine (Nif) 0.5 mg.kg-1 i.v. reduced APD and increased the HR in rabbit. In guinea pig left atrium, FDP and Nif decreased the APD, the effects of acetylcholine to shorten the APD was antagonized by FDP 1 mumol.L-1. In rabbit's sinoatrial nodes, FDP 0.5, 1 mumol.L-1 also suppressed the APA and increased the spontaneous sinus cycle length (SCL) and APD50. These results indicate that FDP may inhibit the Ca2+ and K+ currents of myocardium.

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Authors+Show Affiliations

Liu DQ
Department of Pharmacology, Fourth Military Medical Univesity, Xi-an, China.
Zhou SS
No affiliation info available
Zhao DH
No affiliation info available
Sheng BH
No affiliation info available

MeSH

AcetylcholineAction PotentialsAnimalsAtrial FunctionCalcium Channel BlockersDihydropyridinesFemaleGuinea PigsHeart RateIn Vitro TechniquesMaleMicroelectrodesMyocardiumNifedipineRabbitsSinoatrial NodeVentricular Function

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

8352012

Citation

Liu, D Q., et al. "[Effects of Furyl-dihydropyridine On Action Potential Ventricular Myocardium of Rabbit in Vivo and Isolated Guinea Pig Left Atrium in Vitro]." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 14, no. 2, 1993, pp. 164-7.
Liu DQ, Zhou SS, Zhao DH, et al. [Effects of furyl-dihydropyridine on action potential ventricular myocardium of rabbit in vivo and isolated guinea pig left atrium in vitro]. Zhongguo Yao Li Xue Bao. 1993;14(2):164-7.
Liu, D. Q., Zhou, S. S., Zhao, D. H., & Sheng, B. H. (1993). [Effects of furyl-dihydropyridine on action potential ventricular myocardium of rabbit in vivo and isolated guinea pig left atrium in vitro]. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 14(2), 164-7.
Liu DQ, et al. [Effects of Furyl-dihydropyridine On Action Potential Ventricular Myocardium of Rabbit in Vivo and Isolated Guinea Pig Left Atrium in Vitro]. Zhongguo Yao Li Xue Bao. 1993;14(2):164-7. PubMed PMID: 8352012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of furyl-dihydropyridine on action potential ventricular myocardium of rabbit in vivo and isolated guinea pig left atrium in vitro]. AU - Liu,D Q, AU - Zhou,S S, AU - Zhao,D H, AU - Sheng,B H, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 164 EP - 7 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 14 IS - 2 N2 - Effects of furyl-dihydropyridine (FDP) on action potential of rabbit ventricular myocardium in vivo were observed with floating microelectrode technique. FDP 0.5 mg.kg-1 i.v. increased APD30 from 104 +/- 7 to 127 +/- 7 ms, APD90 from 146 +/- 10 to 177 +/- 9 ms (P < 0.01, n = 7), decreased the heart rate from 230 +/- 18 to 203 +/- 20 bpm (P < 0.05). Nifedipine (Nif) 0.5 mg.kg-1 i.v. reduced APD and increased the HR in rabbit. In guinea pig left atrium, FDP and Nif decreased the APD, the effects of acetylcholine to shorten the APD was antagonized by FDP 1 mumol.L-1. In rabbit's sinoatrial nodes, FDP 0.5, 1 mumol.L-1 also suppressed the APA and increased the spontaneous sinus cycle length (SCL) and APD50. These results indicate that FDP may inhibit the Ca2+ and K+ currents of myocardium. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/8352012/[Effects_of_furyl_dihydropyridine_on_action_potential_ventricular_myocardium_of_rabbit_in_vivo_and_isolated_guinea_pig_left_atrium_in_vitro]_ L2 - http://www.chinaphar.com/1671-4083/14/164.pdf DB - PRIME DP - Unbound Medicine ER -