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Characterisation of the central nervous depressant activity of a commercially available valerian root extract.
Arzneimittelforschung. 1993 Jun; 43(6):638-41.A

Abstract

The evaluation of a commercially available valerian root extract (Valdispert) revealed pronounced sedative properties in the mouse with respect to a reduction in motility and an increase in the thiopental sleeping-time. A direct comparison with diazepam and chlorpromazine revealed a moderate sedative activity for the tested extract. The extract showed only weak anticonvulsive properties.

Authors+Show Affiliations

Leuschner J
LPT Laboratory of Pharmacology, Hamburg, Fed. Rep. of Germany.
Müller J
No affiliation info available
Rudmann M
No affiliation info available

MeSH

AnimalsAnticonvulsantsCentral Nervous System DepressantsChlorpromazineDiazepamFemaleMiceMotor ActivityPentylenetetrazolePlant ExtractsPlants, MedicinalSleepThiopentalValerian

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8352816

Citation

Leuschner, J, et al. "Characterisation of the Central Nervous Depressant Activity of a Commercially Available Valerian Root Extract." Arzneimittel-Forschung, vol. 43, no. 6, 1993, pp. 638-41.
Leuschner J, Müller J, Rudmann M. Characterisation of the central nervous depressant activity of a commercially available valerian root extract. Arzneimittelforschung. 1993;43(6):638-41.
Leuschner, J., Müller, J., & Rudmann, M. (1993). Characterisation of the central nervous depressant activity of a commercially available valerian root extract. Arzneimittel-Forschung, 43(6), 638-41.
Leuschner J, Müller J, Rudmann M. Characterisation of the Central Nervous Depressant Activity of a Commercially Available Valerian Root Extract. Arzneimittelforschung. 1993;43(6):638-41. PubMed PMID: 8352816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterisation of the central nervous depressant activity of a commercially available valerian root extract. AU - Leuschner,J, AU - Müller,J, AU - Rudmann,M, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 638 EP - 41 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 43 IS - 6 N2 - The evaluation of a commercially available valerian root extract (Valdispert) revealed pronounced sedative properties in the mouse with respect to a reduction in motility and an increase in the thiopental sleeping-time. A direct comparison with diazepam and chlorpromazine revealed a moderate sedative activity for the tested extract. The extract showed only weak anticonvulsive properties. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/8352816/Characterisation_of_the_central_nervous_depressant_activity_of_a_commercially_available_valerian_root_extract_ DB - PRIME DP - Unbound Medicine ER -