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A feature of alcoholic Wernicke's encephalopathy favourable to the maintenance of memory function: vomiting.
Alcohol Alcohol. 1993 May; 28(3):339-45.AA

Abstract

Outcome in terms of progression of Korsakoff's psychosis is known to be unlikely when the preceding thiamin deficiency syndrome, Wernicke's encephalopathy, does not follow heavy alcohol use. There is evidence that alcohol potentiates thiamin-related brain damage. It is argued here that in heavy drinkers, if vomiting precedes the onset of the encephalopathy, then the latter might develop at a time when tissue alcohol levels are close to zero. Any progression to Korsakoff's psychosis could then be associated with less or even no impairment. This outcome would not be expected if ingestion of alcohol continued during the vomiting stage. In a follow-up study of 61 cases of alcoholic Wernicke's encephalopathy, these concepts are given some support by the results obtained.

Authors+Show Affiliations

Price J
Department of Psychiatry, Royal Brisbane Hospital, Qld, Australia.
Hicks M
No affiliation info available
Williams G
No affiliation info available

MeSH

AgedAlcohol Amnestic DisorderAlcohol DrinkingAlcoholismEthanolFemaleHumansMaleMiddle AgedRetrospective StudiesThiamine DeficiencyVomitingWechsler ScalesWernicke Encephalopathy

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8352845

Citation

Price, J, et al. "A Feature of Alcoholic Wernicke's Encephalopathy Favourable to the Maintenance of Memory Function: Vomiting." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 28, no. 3, 1993, pp. 339-45.
Price J, Hicks M, Williams G. A feature of alcoholic Wernicke's encephalopathy favourable to the maintenance of memory function: vomiting. Alcohol Alcohol. 1993;28(3):339-45.
Price, J., Hicks, M., & Williams, G. (1993). A feature of alcoholic Wernicke's encephalopathy favourable to the maintenance of memory function: vomiting. Alcohol and Alcoholism (Oxford, Oxfordshire), 28(3), 339-45.
Price J, Hicks M, Williams G. A Feature of Alcoholic Wernicke's Encephalopathy Favourable to the Maintenance of Memory Function: Vomiting. Alcohol Alcohol. 1993;28(3):339-45. PubMed PMID: 8352845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A feature of alcoholic Wernicke's encephalopathy favourable to the maintenance of memory function: vomiting. AU - Price,J, AU - Hicks,M, AU - Williams,G, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 339 EP - 45 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 28 IS - 3 N2 - Outcome in terms of progression of Korsakoff's psychosis is known to be unlikely when the preceding thiamin deficiency syndrome, Wernicke's encephalopathy, does not follow heavy alcohol use. There is evidence that alcohol potentiates thiamin-related brain damage. It is argued here that in heavy drinkers, if vomiting precedes the onset of the encephalopathy, then the latter might develop at a time when tissue alcohol levels are close to zero. Any progression to Korsakoff's psychosis could then be associated with less or even no impairment. This outcome would not be expected if ingestion of alcohol continued during the vomiting stage. In a follow-up study of 61 cases of alcoholic Wernicke's encephalopathy, these concepts are given some support by the results obtained. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/8352845/A_feature_of_alcoholic_Wernicke's_encephalopathy_favourable_to_the_maintenance_of_memory_function:_vomiting_ L2 - https://www.diseaseinfosearch.org/result/7414 DB - PRIME DP - Unbound Medicine ER -