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Use of the microdialysis technique in the monitoring of subcutaneous tissue glucose concentration.
Int J Artif Organs. 1993 May; 16(5):268-75.IJ

Abstract

For some time the subcutaneous (s.c.) tissue has been the target for continuous glucose measurement. The microdialysis technique permits an extracellular region approach, which has been used for about two decades for measuring various metabolites in dialysates obtained from different body regions. By connecting a s.c. implanted microdialysis probe to a flow chamber of an amperometric glucose sensor, the procedure of glucose sensing was transferred to ex vivo. Using this device it was possible to obtain, for up to 24 hours, s.c. tissue glucose profiles of healthy and diabetic people. The microdialysis theory, the calibration process and other microdialysis technique applications are discussed in this paper. Although the combination of the microdialysis technique and amperometric glucose sensing requires certain technical equipment, the combination of microdialysis and glucose sensor seems to be a promising approach to a continuously functioning glucose sensing system.

Authors+Show Affiliations

Insitut für Diabetes Technologie an der Universität Ulm, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8354586

Citation

Meyerhoff, C, et al. "Use of the Microdialysis Technique in the Monitoring of Subcutaneous Tissue Glucose Concentration." The International Journal of Artificial Organs, vol. 16, no. 5, 1993, pp. 268-75.
Meyerhoff C, Bischof F, Mennel FJ, et al. Use of the microdialysis technique in the monitoring of subcutaneous tissue glucose concentration. Int J Artif Organs. 1993;16(5):268-75.
Meyerhoff, C., Bischof, F., Mennel, F. J., Sternberg, F., & Pfeiffer, E. F. (1993). Use of the microdialysis technique in the monitoring of subcutaneous tissue glucose concentration. The International Journal of Artificial Organs, 16(5), 268-75.
Meyerhoff C, et al. Use of the Microdialysis Technique in the Monitoring of Subcutaneous Tissue Glucose Concentration. Int J Artif Organs. 1993;16(5):268-75. PubMed PMID: 8354586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of the microdialysis technique in the monitoring of subcutaneous tissue glucose concentration. AU - Meyerhoff,C, AU - Bischof,F, AU - Mennel,F J, AU - Sternberg,F, AU - Pfeiffer,E F, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 268 EP - 75 JF - The International journal of artificial organs JO - Int J Artif Organs VL - 16 IS - 5 N2 - For some time the subcutaneous (s.c.) tissue has been the target for continuous glucose measurement. The microdialysis technique permits an extracellular region approach, which has been used for about two decades for measuring various metabolites in dialysates obtained from different body regions. By connecting a s.c. implanted microdialysis probe to a flow chamber of an amperometric glucose sensor, the procedure of glucose sensing was transferred to ex vivo. Using this device it was possible to obtain, for up to 24 hours, s.c. tissue glucose profiles of healthy and diabetic people. The microdialysis theory, the calibration process and other microdialysis technique applications are discussed in this paper. Although the combination of the microdialysis technique and amperometric glucose sensing requires certain technical equipment, the combination of microdialysis and glucose sensor seems to be a promising approach to a continuously functioning glucose sensing system. SN - 0391-3988 UR - https://www.unboundmedicine.com/medline/citation/8354586/Use_of_the_microdialysis_technique_in_the_monitoring_of_subcutaneous_tissue_glucose_concentration_ L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -