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Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse.
Parasite Immunol. 1993 Jun; 15(6):349-54.PI

Abstract

Effects of depressed eosinophilia on the development of Angiostrongylus cantonensis in the mouse were studied using monoclonal rat anti-mouse-interleukin-5 antibody (anti-IL-5). The administration of anti-IL-5 strongly depressed peripheral, cerebrospinal fluid (CSF) and medullary eosinophilic responses in mice infected with A. cantonensis, when compared with groups treated with phosphate-buffered saline solution (PBS) alone or isotype-matched rat IgG. There was no significant difference in A. cantonensis antigen specific IgG and IgE antibody responses between rat IgG treated and anti-IL-5 treated mice. Intracranial worm recovery in anti-IL-5 treated mice was consistently high throughout the course of the study and some worms migrated from the brain to the lungs. By contrast, almost all the intracranial worms in the mouse groups treated with PBS alone or rat IgG died before day 32. These data clearly indicate that IL-5 is essential for eosinophil responses in A. cantonensis infected mice and also that eosinophils serve as a potential effector cell in the killing of the intracranial worms in mice.

Authors+Show Affiliations

Department of Animal Science, Akita Prefectural College of Agriculture, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8361777

Citation

Sasaki, O, et al. "Ablation of Eosinophils With anti-IL-5 Antibody Enhances the Survival of Intracranial Worms of Angiostrongylus Cantonensis in the Mouse." Parasite Immunology, vol. 15, no. 6, 1993, pp. 349-54.
Sasaki O, Sugaya H, Ishida K, et al. Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse. Parasite Immunol. 1993;15(6):349-54.
Sasaki, O., Sugaya, H., Ishida, K., & Yoshimura, K. (1993). Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse. Parasite Immunology, 15(6), 349-54.
Sasaki O, et al. Ablation of Eosinophils With anti-IL-5 Antibody Enhances the Survival of Intracranial Worms of Angiostrongylus Cantonensis in the Mouse. Parasite Immunol. 1993;15(6):349-54. PubMed PMID: 8361777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse. AU - Sasaki,O, AU - Sugaya,H, AU - Ishida,K, AU - Yoshimura,K, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 349 EP - 54 JF - Parasite immunology JO - Parasite Immunol VL - 15 IS - 6 N2 - Effects of depressed eosinophilia on the development of Angiostrongylus cantonensis in the mouse were studied using monoclonal rat anti-mouse-interleukin-5 antibody (anti-IL-5). The administration of anti-IL-5 strongly depressed peripheral, cerebrospinal fluid (CSF) and medullary eosinophilic responses in mice infected with A. cantonensis, when compared with groups treated with phosphate-buffered saline solution (PBS) alone or isotype-matched rat IgG. There was no significant difference in A. cantonensis antigen specific IgG and IgE antibody responses between rat IgG treated and anti-IL-5 treated mice. Intracranial worm recovery in anti-IL-5 treated mice was consistently high throughout the course of the study and some worms migrated from the brain to the lungs. By contrast, almost all the intracranial worms in the mouse groups treated with PBS alone or rat IgG died before day 32. These data clearly indicate that IL-5 is essential for eosinophil responses in A. cantonensis infected mice and also that eosinophils serve as a potential effector cell in the killing of the intracranial worms in mice. SN - 0141-9838 UR - https://www.unboundmedicine.com/medline/citation/8361777/Ablation_of_eosinophils_with_anti_IL_5_antibody_enhances_the_survival_of_intracranial_worms_of_Angiostrongylus_cantonensis_in_the_mouse_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0141-9838&date=1993&volume=15&issue=6&spage=349 DB - PRIME DP - Unbound Medicine ER -