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Lyme disease and pregnancy outcome: a prospective study of two thousand prenatal patients.

Abstract

OBJECTIVE

The purpose of the study was to determine if prenatal exposure to Lyme disease was associated with an increased risk of adverse pregnancy outcome.

STUDY DESIGN

Approximately 2000 Westchester County, New York, women completed questionnaires and had sera tested for antibody to Borrelia burgdorferi at their first prenatal visit and at delivery. Fetal death, birth weight, length of gestation at delivery, and congenital malformations were examined in relation to maternal Lyme disease exposure before and during pregnancy.

RESULTS

Maternal Lyme disease or an increased risk of exposure to Lyme disease was not associated with fetal death, decreased birth weight, or length of gestation at delivery. Tick bites or Lyme disease around the time of conception was not associated with congenital malformations. Tick bites within 3 years preceding conception were significantly associated with congenital malformations, but this could have reflected reporting differences between exposed and unexposed women.

CONCLUSIONS

Maternal exposure to Lyme disease before conception or during pregnancy is not associated with fetal death, prematurity, or congenital malformations taken as a whole. We have not ruled out the possibility that exposure to Lyme disease as defined by maternal history increases the risk of specific malformations or has an effect if it is not treated. We have insufficient numbers of women who were seropositive at their first prenatal visit to determine if this subgroup of exposed women are at a moderately increased risk of having a child with a congenital abnormality. The low frequency of seroconversion at delivery in this endemic area suggests that preventive measures are being taken by obstetricians and patients.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pediatrics, New York Medical College, Valhalla 10595.

    , , ,

    Source

    American journal of obstetrics and gynecology 169:2 Pt 1 1993 Aug pg 367-74

    MeSH

    Congenital Abnormalities
    Environmental Exposure
    Female
    Humans
    Lyme Disease
    New York
    Pregnancy
    Pregnancy Complications, Infectious
    Pregnancy Outcome
    Prospective Studies

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8362948

    Citation

    TY - JOUR T1 - Lyme disease and pregnancy outcome: a prospective study of two thousand prenatal patients. AU - Strobino,B A, AU - Williams,C L, AU - Abid,S, AU - Chalson,R, AU - Spierling,P, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 367 EP - 74 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 169 IS - 2 Pt 1 N2 - OBJECTIVE: The purpose of the study was to determine if prenatal exposure to Lyme disease was associated with an increased risk of adverse pregnancy outcome. STUDY DESIGN: Approximately 2000 Westchester County, New York, women completed questionnaires and had sera tested for antibody to Borrelia burgdorferi at their first prenatal visit and at delivery. Fetal death, birth weight, length of gestation at delivery, and congenital malformations were examined in relation to maternal Lyme disease exposure before and during pregnancy. RESULTS: Maternal Lyme disease or an increased risk of exposure to Lyme disease was not associated with fetal death, decreased birth weight, or length of gestation at delivery. Tick bites or Lyme disease around the time of conception was not associated with congenital malformations. Tick bites within 3 years preceding conception were significantly associated with congenital malformations, but this could have reflected reporting differences between exposed and unexposed women. CONCLUSIONS: Maternal exposure to Lyme disease before conception or during pregnancy is not associated with fetal death, prematurity, or congenital malformations taken as a whole. We have not ruled out the possibility that exposure to Lyme disease as defined by maternal history increases the risk of specific malformations or has an effect if it is not treated. We have insufficient numbers of women who were seropositive at their first prenatal visit to determine if this subgroup of exposed women are at a moderately increased risk of having a child with a congenital abnormality. The low frequency of seroconversion at delivery in this endemic area suggests that preventive measures are being taken by obstetricians and patients. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/8362948/abstract/Lyme_disease_and_pregnancy_outcome:_a_prospective_study_of_two_thousand_prenatal_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(93)90088-Z ER -