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The Lynch syndromes.

Abstract

The Lynch syndromes, also referred to as hereditary nonpolyposis colorectal cancer, are reviewed, with particular attention given to their natural history, diagnosis, surveillance, and management. Lynch syndrome I is characterized by an autosomal dominantly inherited predisposition to early onset colorectal cancer, with proximal predominance and an excess of synchronous and metachronous colorectal cancers. Lynch syndrome II manifests all of the features of Lynch syndrome I but, in addition, shows an integral association with extracolonic cancers, particularly carcinomas of the endometrium and the ovary. There are no premonitory physical signs or biomarkers of genotypic risk. Therefore, the natural history features of the Lynch syndromes are crucial to their surveillance and management.

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  • Authors+Show Affiliations

    ,

    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178.

    Source

    Current opinion in oncology 5:4 1993 Jul pg 687-96

    MeSH

    Adenocarcinoma
    Adenoma
    Adolescent
    Adult
    Child
    Colorectal Neoplasms
    Colorectal Neoplasms, Hereditary Nonpolyposis
    Family Health
    Female
    Humans
    Male
    Pedigree

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    8364086

    Citation

    Lynch, H T., and J F. Lynch. "The Lynch Syndromes." Current Opinion in Oncology, vol. 5, no. 4, 1993, pp. 687-96.
    Lynch HT, Lynch JF. The Lynch syndromes. Curr Opin Oncol. 1993;5(4):687-96.
    Lynch, H. T., & Lynch, J. F. (1993). The Lynch syndromes. Current Opinion in Oncology, 5(4), pp. 687-96.
    Lynch HT, Lynch JF. The Lynch Syndromes. Curr Opin Oncol. 1993;5(4):687-96. PubMed PMID: 8364086.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Lynch syndromes. AU - Lynch,H T, AU - Lynch,J F, PY - 1993/7/1/pubmed PY - 1993/7/1/medline PY - 1993/7/1/entrez SP - 687 EP - 96 JF - Current opinion in oncology JO - Curr Opin Oncol VL - 5 IS - 4 N2 - The Lynch syndromes, also referred to as hereditary nonpolyposis colorectal cancer, are reviewed, with particular attention given to their natural history, diagnosis, surveillance, and management. Lynch syndrome I is characterized by an autosomal dominantly inherited predisposition to early onset colorectal cancer, with proximal predominance and an excess of synchronous and metachronous colorectal cancers. Lynch syndrome II manifests all of the features of Lynch syndrome I but, in addition, shows an integral association with extracolonic cancers, particularly carcinomas of the endometrium and the ovary. There are no premonitory physical signs or biomarkers of genotypic risk. Therefore, the natural history features of the Lynch syndromes are crucial to their surveillance and management. SN - 1040-8746 UR - https://www.unboundmedicine.com/medline/citation/8364086/The_Lynch_syndromes_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8364086.ui DB - PRIME DP - Unbound Medicine ER -