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The Lynch syndromes.
Curr Opin Oncol 1993; 5(4):687-96CO

Abstract

The Lynch syndromes, also referred to as hereditary nonpolyposis colorectal cancer, are reviewed, with particular attention given to their natural history, diagnosis, surveillance, and management. Lynch syndrome I is characterized by an autosomal dominantly inherited predisposition to early onset colorectal cancer, with proximal predominance and an excess of synchronous and metachronous colorectal cancers. Lynch syndrome II manifests all of the features of Lynch syndrome I but, in addition, shows an integral association with extracolonic cancers, particularly carcinomas of the endometrium and the ovary. There are no premonitory physical signs or biomarkers of genotypic risk. Therefore, the natural history features of the Lynch syndromes are crucial to their surveillance and management.

Authors+Show Affiliations

Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8364086

Citation

Lynch, H T., and J F. Lynch. "The Lynch Syndromes." Current Opinion in Oncology, vol. 5, no. 4, 1993, pp. 687-96.
Lynch HT, Lynch JF. The Lynch syndromes. Curr Opin Oncol. 1993;5(4):687-96.
Lynch, H. T., & Lynch, J. F. (1993). The Lynch syndromes. Current Opinion in Oncology, 5(4), pp. 687-96.
Lynch HT, Lynch JF. The Lynch Syndromes. Curr Opin Oncol. 1993;5(4):687-96. PubMed PMID: 8364086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Lynch syndromes. AU - Lynch,H T, AU - Lynch,J F, PY - 1993/7/1/pubmed PY - 1993/7/1/medline PY - 1993/7/1/entrez SP - 687 EP - 96 JF - Current opinion in oncology JO - Curr Opin Oncol VL - 5 IS - 4 N2 - The Lynch syndromes, also referred to as hereditary nonpolyposis colorectal cancer, are reviewed, with particular attention given to their natural history, diagnosis, surveillance, and management. Lynch syndrome I is characterized by an autosomal dominantly inherited predisposition to early onset colorectal cancer, with proximal predominance and an excess of synchronous and metachronous colorectal cancers. Lynch syndrome II manifests all of the features of Lynch syndrome I but, in addition, shows an integral association with extracolonic cancers, particularly carcinomas of the endometrium and the ovary. There are no premonitory physical signs or biomarkers of genotypic risk. Therefore, the natural history features of the Lynch syndromes are crucial to their surveillance and management. SN - 1040-8746 UR - https://www.unboundmedicine.com/medline/citation/8364086/The_Lynch_syndromes_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8364086.ui DB - PRIME DP - Unbound Medicine ER -