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Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity.
J Pharmacol Exp Ther. 1993 Sep; 266(3):1699-704.JP

Abstract

The protective effect of the reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH4), against the cardiotoxicity of adriamycin (ADR) was evaluated in mice by assay of serum creatine phosphokinase (CPK) and heart lipid peroxide (i.e., thiobarbituric acid reactive substances, TBARS). The activity of CPK was drastically elevated at around 3 days after a single s.c. injection of ADR and had returned to normal at 6 days. There were no marked changes in the TBARS content of the heart by 6 days, but a significant increase was apparent at about 8 days after ADR treatment. The effect of NPH4 was evaluated in terms of the serum CPK activity at the 4th day and in terms of TBARS content at the 8th day after ADR treatment. The elevation of CPK activity induced by ADR was significantly suppressed by two treatments with NPH4 every day for 4 days, i.e., from day 0 to day 3 after injection of ADR, at doses of 3 mg/kg and 0.3 mg/kg. The increase of TBARS content in the heart at 8 days after ADR treatment was also suppressed at both doses of NPH4. The effect of the timing of NPH4 treatment on the suppression of elevated CPK was examined. The suppressive potency of NPH4 could not be elicited by any treatment schedule that terminated at or before 2 days after injection of ADR. Consecutive treatments from day 0 to day 3 after injection of ADR were effective, as was a simple schedule of only two treatments with NPH4 on day 3.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Research Institute for Biosciences, Science University of Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8371168

Citation

Kojima, S, et al. "Inhibitory Effect of 5,6,7,8-tetrahydroneopterin On Adriamycin-induced Cardiotoxicity." The Journal of Pharmacology and Experimental Therapeutics, vol. 266, no. 3, 1993, pp. 1699-704.
Kojima S, Icho T, Hayashi M, et al. Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity. J Pharmacol Exp Ther. 1993;266(3):1699-704.
Kojima, S., Icho, T., Hayashi, M., Kajiwara, Y., Kitabatake, K., & Kubota, K. (1993). Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity. The Journal of Pharmacology and Experimental Therapeutics, 266(3), 1699-704.
Kojima S, et al. Inhibitory Effect of 5,6,7,8-tetrahydroneopterin On Adriamycin-induced Cardiotoxicity. J Pharmacol Exp Ther. 1993;266(3):1699-704. PubMed PMID: 8371168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity. AU - Kojima,S, AU - Icho,T, AU - Hayashi,M, AU - Kajiwara,Y, AU - Kitabatake,K, AU - Kubota,K, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 1699 EP - 704 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 266 IS - 3 N2 - The protective effect of the reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH4), against the cardiotoxicity of adriamycin (ADR) was evaluated in mice by assay of serum creatine phosphokinase (CPK) and heart lipid peroxide (i.e., thiobarbituric acid reactive substances, TBARS). The activity of CPK was drastically elevated at around 3 days after a single s.c. injection of ADR and had returned to normal at 6 days. There were no marked changes in the TBARS content of the heart by 6 days, but a significant increase was apparent at about 8 days after ADR treatment. The effect of NPH4 was evaluated in terms of the serum CPK activity at the 4th day and in terms of TBARS content at the 8th day after ADR treatment. The elevation of CPK activity induced by ADR was significantly suppressed by two treatments with NPH4 every day for 4 days, i.e., from day 0 to day 3 after injection of ADR, at doses of 3 mg/kg and 0.3 mg/kg. The increase of TBARS content in the heart at 8 days after ADR treatment was also suppressed at both doses of NPH4. The effect of the timing of NPH4 treatment on the suppression of elevated CPK was examined. The suppressive potency of NPH4 could not be elicited by any treatment schedule that terminated at or before 2 days after injection of ADR. Consecutive treatments from day 0 to day 3 after injection of ADR were effective, as was a simple schedule of only two treatments with NPH4 on day 3.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/8371168/Inhibitory_effect_of_5678_tetrahydroneopterin_on_adriamycin_induced_cardiotoxicity_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=8371168 DB - PRIME DP - Unbound Medicine ER -