Tags

Type your tag names separated by a space and hit enter

The involvement of D1 and D2 dopamine receptors in amphetamine-induced changes in striatal unit activity in behaving rats.
Brain Res. 1993 Aug 13; 619(1-2):347-51.BR

Abstract

Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently blocked amphetamine-induced neuronal excitations as did eticlopride (0.25 and 1.0 mg/kg). In contrast, (-)-sulpiride (10, 20 and 40 mg/kg) failed to alter the neuronal response to amphetamine. Similarly, SCH-23390 and eticlopride also blocked the behavioral effects of amphetamine, but sulpiride did not. Collectively, these results support the involvement of D1 and D2 dopamine receptors in the excitatory effects of amphetamine on striatal neurons, but suggest caution in assessing the neuronal and behavioral effects of sulpiride.

Authors+Show Affiliations

Department of Psychology, Indiana University, Bloomington 47405.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8374790

Citation

Rosa-Kenig, A, et al. "The Involvement of D1 and D2 Dopamine Receptors in Amphetamine-induced Changes in Striatal Unit Activity in Behaving Rats." Brain Research, vol. 619, no. 1-2, 1993, pp. 347-51.
Rosa-Kenig A, Puotz JK, Rebec GV. The involvement of D1 and D2 dopamine receptors in amphetamine-induced changes in striatal unit activity in behaving rats. Brain Res. 1993;619(1-2):347-51.
Rosa-Kenig, A., Puotz, J. K., & Rebec, G. V. (1993). The involvement of D1 and D2 dopamine receptors in amphetamine-induced changes in striatal unit activity in behaving rats. Brain Research, 619(1-2), 347-51.
Rosa-Kenig A, Puotz JK, Rebec GV. The Involvement of D1 and D2 Dopamine Receptors in Amphetamine-induced Changes in Striatal Unit Activity in Behaving Rats. Brain Res. 1993 Aug 13;619(1-2):347-51. PubMed PMID: 8374790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The involvement of D1 and D2 dopamine receptors in amphetamine-induced changes in striatal unit activity in behaving rats. AU - Rosa-Kenig,A, AU - Puotz,J K, AU - Rebec,G V, PY - 1993/8/13/pubmed PY - 1993/8/13/medline PY - 1993/8/13/entrez SP - 347 EP - 51 JF - Brain research JO - Brain Res VL - 619 IS - 1-2 N2 - Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently blocked amphetamine-induced neuronal excitations as did eticlopride (0.25 and 1.0 mg/kg). In contrast, (-)-sulpiride (10, 20 and 40 mg/kg) failed to alter the neuronal response to amphetamine. Similarly, SCH-23390 and eticlopride also blocked the behavioral effects of amphetamine, but sulpiride did not. Collectively, these results support the involvement of D1 and D2 dopamine receptors in the excitatory effects of amphetamine on striatal neurons, but suggest caution in assessing the neuronal and behavioral effects of sulpiride. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/8374790/The_involvement_of_D1_and_D2_dopamine_receptors_in_amphetamine_induced_changes_in_striatal_unit_activity_in_behaving_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(93)91633-4 DB - PRIME DP - Unbound Medicine ER -