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Citrate uptake and oxidation by fragments of rat ventral prostate.
Enzyme. 1977; 22(1):45-51.E

Abstract

Citrate oxidation was studied utilizing an in vitro preparation of rat ventral prostate which was very similar, with respect to citrate metabolish, to the intact prostate. The rate of citrate oxidation was very slow in comparison to kidney, although citrate entered prostatic tissue and accumulated intracellularly. Citrate was converted to isocitrate at a rate which resulted in a constant citrate/isocitrate ratio over a 10-fold variation in medium citrate concentration. The prostate oxidized significantly more alpha-ketoglutarate and malate than citrate. These results suggested that limited citrate oxidation could account for the accumulation of high prostatic citrate levels.

Authors

Franklin RB
No affiliation info available
Costello LC
No affiliation info available
Littleton GK
No affiliation info available

MeSH

AnimalsBiological TransportCitratesIn Vitro TechniquesIsocitratesKidneyKineticsMalatesMaleOrgan SpecificityOxidation-ReductionProstateRats

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

837893

Citation

Franklin, R B., et al. "Citrate Uptake and Oxidation By Fragments of Rat Ventral Prostate." Enzyme, vol. 22, no. 1, 1977, pp. 45-51.
Franklin RB, Costello LC, Littleton GK. Citrate uptake and oxidation by fragments of rat ventral prostate. Enzyme. 1977;22(1):45-51.
Franklin, R. B., Costello, L. C., & Littleton, G. K. (1977). Citrate uptake and oxidation by fragments of rat ventral prostate. Enzyme, 22(1), 45-51.
Franklin RB, Costello LC, Littleton GK. Citrate Uptake and Oxidation By Fragments of Rat Ventral Prostate. Enzyme. 1977;22(1):45-51. PubMed PMID: 837893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Citrate uptake and oxidation by fragments of rat ventral prostate. AU - Franklin,R B, AU - Costello,L C, AU - Littleton,G K, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez SP - 45 EP - 51 JF - Enzyme JO - Enzyme VL - 22 IS - 1 N2 - Citrate oxidation was studied utilizing an in vitro preparation of rat ventral prostate which was very similar, with respect to citrate metabolish, to the intact prostate. The rate of citrate oxidation was very slow in comparison to kidney, although citrate entered prostatic tissue and accumulated intracellularly. Citrate was converted to isocitrate at a rate which resulted in a constant citrate/isocitrate ratio over a 10-fold variation in medium citrate concentration. The prostate oxidized significantly more alpha-ketoglutarate and malate than citrate. These results suggested that limited citrate oxidation could account for the accumulation of high prostatic citrate levels. SN - 0013-9432 UR - https://www.unboundmedicine.com/medline/citation/837893/Citrate_uptake_and_oxidation_by_fragments_of_rat_ventral_prostate_ DB - PRIME DP - Unbound Medicine ER -