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The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms.

Abstract

Gamma-linolenic acid (GLA) has recently been found to be beneficial in the management of breast pain and of diabetic neuropathy. GLA is a precursor of unsaturated fatty acids which are important in membrane structures, as second messengers in their own right and as precursors of eicosanoids. While the mechanisms of GLA action are likely to be complex, non-eicosanoid effects are probably of substantial importance. These effects include modification of membrane fluidity and of the functions of lipid-associated receptors and changes in the inositol cycle.

Authors+Show Affiliations

Efamol Research Institute, Kentville, Nova Scotia, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8380930

Citation

Horrobin, D F.. "The Effects of Gamma-linolenic Acid On Breast Pain and Diabetic Neuropathy: Possible Non-eicosanoid Mechanisms." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 48, no. 1, 1993, pp. 101-4.
Horrobin DF. The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. Prostaglandins Leukot Essent Fatty Acids. 1993;48(1):101-4.
Horrobin, D. F. (1993). The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 48(1), pp. 101-4.
Horrobin DF. The Effects of Gamma-linolenic Acid On Breast Pain and Diabetic Neuropathy: Possible Non-eicosanoid Mechanisms. Prostaglandins Leukot Essent Fatty Acids. 1993;48(1):101-4. PubMed PMID: 8380930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. A1 - Horrobin,D F, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 101 EP - 4 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 48 IS - 1 N2 - Gamma-linolenic acid (GLA) has recently been found to be beneficial in the management of breast pain and of diabetic neuropathy. GLA is a precursor of unsaturated fatty acids which are important in membrane structures, as second messengers in their own right and as precursors of eicosanoids. While the mechanisms of GLA action are likely to be complex, non-eicosanoid effects are probably of substantial importance. These effects include modification of membrane fluidity and of the functions of lipid-associated receptors and changes in the inositol cycle. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/8380930/The_effects_of_gamma_linolenic_acid_on_breast_pain_and_diabetic_neuropathy:_possible_non_eicosanoid_mechanisms_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -