Tags

Type your tag names separated by a space and hit enter

Experimental allergic encephalomyelitis in cobra venom factor-treated and C4-deficient guinea pigs.
Ann Neurol. 1978 Nov; 4(5):427-30.AN

Abstract

Experimental allergic encephalomyelitis (EAE) was studied in guinea pigs with an inherited deficiency of the fourth component of complement (C4) and in guinea pigs injected with cobra venom factor to deplete the third component and late-acting components of complement. EAE was elicited by immunization with homologous spinal cord or purified basic protein. Administration of cobra factor after the injection of encephalitogenic emulsion delayed the onset and reduced the intensity of the clinical manifestations of EAE. In addition, cobra factor markedly reduced mortality during the sixty days of observation. However, pathological changes of perivascular infiltration and demyelination were similar in cobra factor-treated and untreated animals. Clinical signs of EAE an mortality in C4-deficient guinea pigs were no different from those in normocomplementemic controls. Thus, although activation of the classic complement pathway does not appear to be involved in the production of EAE in guinea pigs, our results suggest a possible role of the alternative complement pathway in the pathogenesis of EAE.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

83812

Citation

Morariu, M A., and A P. Dalmasso. "Experimental Allergic Encephalomyelitis in Cobra Venom Factor-treated and C4-deficient Guinea Pigs." Annals of Neurology, vol. 4, no. 5, 1978, pp. 427-30.
Morariu MA, Dalmasso AP. Experimental allergic encephalomyelitis in cobra venom factor-treated and C4-deficient guinea pigs. Ann Neurol. 1978;4(5):427-30.
Morariu, M. A., & Dalmasso, A. P. (1978). Experimental allergic encephalomyelitis in cobra venom factor-treated and C4-deficient guinea pigs. Annals of Neurology, 4(5), 427-30.
Morariu MA, Dalmasso AP. Experimental Allergic Encephalomyelitis in Cobra Venom Factor-treated and C4-deficient Guinea Pigs. Ann Neurol. 1978;4(5):427-30. PubMed PMID: 83812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental allergic encephalomyelitis in cobra venom factor-treated and C4-deficient guinea pigs. AU - Morariu,M A, AU - Dalmasso,A P, PY - 1978/11/1/pubmed PY - 1978/11/1/medline PY - 1978/11/1/entrez SP - 427 EP - 30 JF - Annals of neurology JO - Ann Neurol VL - 4 IS - 5 N2 - Experimental allergic encephalomyelitis (EAE) was studied in guinea pigs with an inherited deficiency of the fourth component of complement (C4) and in guinea pigs injected with cobra venom factor to deplete the third component and late-acting components of complement. EAE was elicited by immunization with homologous spinal cord or purified basic protein. Administration of cobra factor after the injection of encephalitogenic emulsion delayed the onset and reduced the intensity of the clinical manifestations of EAE. In addition, cobra factor markedly reduced mortality during the sixty days of observation. However, pathological changes of perivascular infiltration and demyelination were similar in cobra factor-treated and untreated animals. Clinical signs of EAE an mortality in C4-deficient guinea pigs were no different from those in normocomplementemic controls. Thus, although activation of the classic complement pathway does not appear to be involved in the production of EAE in guinea pigs, our results suggest a possible role of the alternative complement pathway in the pathogenesis of EAE. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/83812/Experimental_allergic_encephalomyelitis_in_cobra_venom_factor_treated_and_C4_deficient_guinea_pigs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1978&volume=4&issue=5&spage=427 DB - PRIME DP - Unbound Medicine ER -