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Hormonal chemoprevention of cancer in women.
Science. 1993 Jan 29; 259(5095):633-8.Sci

Abstract

The use of oral contraceptives in the United States during the past three decades has led to a dramatic decline in the incidence of cancers of the ovary and endometrium. The magnitude of these declines was predictable both from epidemiologic data and from the biologic effects of oral contraceptives on these tissues. Although the incidence of breast cancer has not been substantially affected by current oral contraceptives, it may be possible to develop alternative forms of contraception that provide protection against all three cancers. The major goal of hormonal chemoprevention of cancer is to reduce cell proliferation in the relevant epithelial tissue. New chemopreventive agents such as tamoxifen exemplify the application of this principle.

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Authors+Show Affiliations

Henderson BE
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Ross RK
No affiliation info available
Pike MC
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdultAge FactorsAgedAndrostenesAnticarcinogenic AgentsAzasteroidsBreast NeoplasmsContraceptives, OralEndometrial NeoplasmsEstrogen Replacement TherapyFemaleFinasterideHumansIncidenceMaleMiddle AgedOvarian NeoplasmsProgestinsProstatic NeoplasmsTamoxifenUnited KingdomUnited States

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8381558

Citation

Henderson, B E., et al. "Hormonal Chemoprevention of Cancer in Women." Science (New York, N.Y.), vol. 259, no. 5095, 1993, pp. 633-8.
Henderson BE, Ross RK, Pike MC. Hormonal chemoprevention of cancer in women. Science. 1993;259(5095):633-8.
Henderson, B. E., Ross, R. K., & Pike, M. C. (1993). Hormonal chemoprevention of cancer in women. Science (New York, N.Y.), 259(5095), 633-8.
Henderson BE, Ross RK, Pike MC. Hormonal Chemoprevention of Cancer in Women. Science. 1993 Jan 29;259(5095):633-8. PubMed PMID: 8381558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal chemoprevention of cancer in women. AU - Henderson,B E, AU - Ross,R K, AU - Pike,M C, PY - 1993/1/29/pubmed PY - 1993/1/29/medline PY - 1993/1/29/entrez SP - 633 EP - 8 JF - Science (New York, N.Y.) JO - Science VL - 259 IS - 5095 N2 - The use of oral contraceptives in the United States during the past three decades has led to a dramatic decline in the incidence of cancers of the ovary and endometrium. The magnitude of these declines was predictable both from epidemiologic data and from the biologic effects of oral contraceptives on these tissues. Although the incidence of breast cancer has not been substantially affected by current oral contraceptives, it may be possible to develop alternative forms of contraception that provide protection against all three cancers. The major goal of hormonal chemoprevention of cancer is to reduce cell proliferation in the relevant epithelial tissue. New chemopreventive agents such as tamoxifen exemplify the application of this principle. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/8381558/Hormonal_chemoprevention_of_cancer_in_women_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8381558 DB - PRIME DP - Unbound Medicine ER -