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Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection.
AIDS. 1993 Jan; 7(1):33-6.AIDS

Abstract

OBJECTIVE

To assess the value of concentrations of soluble receptors for tumour necrosis factor (sTNFR) as markers for disease progression in HIV infection.

DESIGN

We measured concentrations of sTNFR in the serum of 32 HIV-infected male patients in various stages of disease and in 12 healthy male control subjects. Correlations between the levels of sTNFR and CD4+ lymphocyte counts were calculated.

RESULTS

Serum levels of sTNFR p55 and p75 were elevated in parallel with severity of clinical stage. sTNFR p55 levels were higher at later stages of HIV infection (Centers for Disease Control stage IV) with or without concurrent illness, whereas sTNFR p75 was already elevated in asymptomatic carriers, compared with controls. There was an inverse correlation between sTNFR concentrations and CD4+ lymphocyte counts.

CONCLUSIONS

Our results suggest that sTNFR concentrations could be potential markers for disease progression in HIV infection.

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Authors+Show Affiliations

Godfried MH
Department of Internal Medicine, University of Amsterdam, The Netherlands.
van der Poll T
No affiliation info available
Jansen J
No affiliation info available
Romijin JA
No affiliation info available
Schattenkerk JK
No affiliation info available
Endert E
No affiliation info available
van Deventer SJ
No affiliation info available
Sauerwein HP
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeAdultBiomarkersHIV InfectionsHumansMaleMiddle AgedReceptors, Cell SurfaceReceptors, Tumor Necrosis FactorSolubilityTumor Necrosis Factor-alpha

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8382926

Citation

Godfried, M H., et al. "Soluble Receptors for Tumour Necrosis Factor: a Putative Marker of Disease Progression in HIV Infection." AIDS (London, England), vol. 7, no. 1, 1993, pp. 33-6.
Godfried MH, van der Poll T, Jansen J, et al. Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection. AIDS. 1993;7(1):33-6.
Godfried, M. H., van der Poll, T., Jansen, J., Romijin, J. A., Schattenkerk, J. K., Endert, E., van Deventer, S. J., & Sauerwein, H. P. (1993). Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection. AIDS (London, England), 7(1), 33-6.
Godfried MH, et al. Soluble Receptors for Tumour Necrosis Factor: a Putative Marker of Disease Progression in HIV Infection. AIDS. 1993;7(1):33-6. PubMed PMID: 8382926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection. AU - Godfried,M H, AU - van der Poll,T, AU - Jansen,J, AU - Romijin,J A, AU - Schattenkerk,J K, AU - Endert,E, AU - van Deventer,S J, AU - Sauerwein,H P, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 33 EP - 6 JF - AIDS (London, England) JO - AIDS VL - 7 IS - 1 N2 - OBJECTIVE: To assess the value of concentrations of soluble receptors for tumour necrosis factor (sTNFR) as markers for disease progression in HIV infection. DESIGN: We measured concentrations of sTNFR in the serum of 32 HIV-infected male patients in various stages of disease and in 12 healthy male control subjects. Correlations between the levels of sTNFR and CD4+ lymphocyte counts were calculated. RESULTS: Serum levels of sTNFR p55 and p75 were elevated in parallel with severity of clinical stage. sTNFR p55 levels were higher at later stages of HIV infection (Centers for Disease Control stage IV) with or without concurrent illness, whereas sTNFR p75 was already elevated in asymptomatic carriers, compared with controls. There was an inverse correlation between sTNFR concentrations and CD4+ lymphocyte counts. CONCLUSIONS: Our results suggest that sTNFR concentrations could be potential markers for disease progression in HIV infection. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/8382926/Soluble_receptors_for_tumour_necrosis_factor:_a_putative_marker_of_disease_progression_in_HIV_infection_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8382926.ui DB - PRIME DP - Unbound Medicine ER -