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Patterns of sensory nerve conduction abnormalities in demyelinating and axonal peripheral nerve disorders.
Muscle Nerve. 1993 Mar; 16(3):262-6.MN

Abstract

The pattern of an abnormal median-normal sural (AMNS) sensory response is associated with acute and chronic inflammatory demyelinating polyradiculoneuropathy (AIDP and CIDP) and considered unusual in other types of neuropathy, although specificity and sensitivity of this pattern have not been evaluated. We compared sensory responses (patterns and absolute values) in patients with AIDP, CIDP, diabetic polyneuropathy (DP), and motor neuron disease (MND). Using strict criteria, the AMNS pattern occurred more frequently in recent onset AIDP (39%) compared with CIDP (28%), DP (14%-23%), or MND (22%) patients. This pattern was found in 3% of control subjects. The extreme pattern of an absent median-present sural response occurred only in AIDP and CIDP patients and in no other groups. Abnormalities of both nerves were more common in long-standing polyneuropathies such as CIDP and DP compared with AIDP or MND. Median nerve amplitudes were reduced significantly in AIDP, CIDP, and DP patients compared with MND patients, whereas sural nerve amplitudes were significantly reduced only in DP and CIDP patients. These findings may reflect early distal nerve involvement particularly in AIDP patients which is highlighted by differences in median and sural nerve recording electrode placement. We conclude that, in the appropriate clinical setting, the AMNS pattern, an absent median-present sural response pattern, or a reduced median amplitude compared with the sural amplitude supports a diagnosis of a primary demyelinating polyneuropathy.

Authors+Show Affiliations

Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109-0316.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8383290

Citation

Bromberg, M B., and J W. Albers. "Patterns of Sensory Nerve Conduction Abnormalities in Demyelinating and Axonal Peripheral Nerve Disorders." Muscle & Nerve, vol. 16, no. 3, 1993, pp. 262-6.
Bromberg MB, Albers JW. Patterns of sensory nerve conduction abnormalities in demyelinating and axonal peripheral nerve disorders. Muscle Nerve. 1993;16(3):262-6.
Bromberg, M. B., & Albers, J. W. (1993). Patterns of sensory nerve conduction abnormalities in demyelinating and axonal peripheral nerve disorders. Muscle & Nerve, 16(3), 262-6.
Bromberg MB, Albers JW. Patterns of Sensory Nerve Conduction Abnormalities in Demyelinating and Axonal Peripheral Nerve Disorders. Muscle Nerve. 1993;16(3):262-6. PubMed PMID: 8383290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of sensory nerve conduction abnormalities in demyelinating and axonal peripheral nerve disorders. AU - Bromberg,M B, AU - Albers,J W, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 262 EP - 6 JF - Muscle & nerve JO - Muscle Nerve VL - 16 IS - 3 N2 - The pattern of an abnormal median-normal sural (AMNS) sensory response is associated with acute and chronic inflammatory demyelinating polyradiculoneuropathy (AIDP and CIDP) and considered unusual in other types of neuropathy, although specificity and sensitivity of this pattern have not been evaluated. We compared sensory responses (patterns and absolute values) in patients with AIDP, CIDP, diabetic polyneuropathy (DP), and motor neuron disease (MND). Using strict criteria, the AMNS pattern occurred more frequently in recent onset AIDP (39%) compared with CIDP (28%), DP (14%-23%), or MND (22%) patients. This pattern was found in 3% of control subjects. The extreme pattern of an absent median-present sural response occurred only in AIDP and CIDP patients and in no other groups. Abnormalities of both nerves were more common in long-standing polyneuropathies such as CIDP and DP compared with AIDP or MND. Median nerve amplitudes were reduced significantly in AIDP, CIDP, and DP patients compared with MND patients, whereas sural nerve amplitudes were significantly reduced only in DP and CIDP patients. These findings may reflect early distal nerve involvement particularly in AIDP patients which is highlighted by differences in median and sural nerve recording electrode placement. We conclude that, in the appropriate clinical setting, the AMNS pattern, an absent median-present sural response pattern, or a reduced median amplitude compared with the sural amplitude supports a diagnosis of a primary demyelinating polyneuropathy. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/8383290/Patterns_of_sensory_nerve_conduction_abnormalities_in_demyelinating_and_axonal_peripheral_nerve_disorders_ L2 - https://doi.org/10.1002/mus.880160304 DB - PRIME DP - Unbound Medicine ER -