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Movement of monovalent ions across the membranes of marginal cells of the stria vascularis in the guinea pig cochlea.
ORL J Otorhinolaryngol Relat Spec. 1993 Mar-Apr; 55(2):61-7.OJ

Abstract

The resting potential and monovalent ions in the marginal cells and scala media were measured before and 20 min after the onset of anoxia using ion-sensitive microelectrodes. The resting potential of the marginal cells decreased from 62.7 to -2.4 mV. The K+ activity decreased from 77.7 to 53.2 mEq/l, while the Na+ activity increased from 2.6 to 24.7 mEq/l. The Cl- activity did not change significantly. In the scala media, the endocochlear potential decreased rapidly from 80.9 to -28.0 mV after the onset of anoxia. The K+ activity decreased from 119.0 to 96.5 mEq/l, the Na+ activity increased from 1.3 to 9.5 mEq/l and that of Cl- decreased from 127.0 to 115.1 mEq/l. The electrochemical gradients determined for each ion based on the ionic changes in the scala media and marginal cells, suggested the existence of an Na/K pump and Na-K-2Cl cotransport at the basolateral membrane of the marginal cells, and a rheogenic K pump and Na-K-2Cl transport at the luminal membrane of the marginal cells. The Na+ and K+ must be recycled at the basolateral membrane and luminal membrane of marginal cells, respectively.

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Authors+Show Affiliations

Komune S
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nakagawa T
No affiliation info available
Hisashi K
No affiliation info available
Kimituki T
No affiliation info available
Uemura T
No affiliation info available

MeSH

AnimalsCell MembraneChloridesCochlear DuctElectrochemistryEndolymphGuinea PigsHypoxiaIon PumpsIon TransportMembrane PotentialsPotassiumSodiumStria Vascularis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8383309

Citation

Komune, S, et al. "Movement of Monovalent Ions Across the Membranes of Marginal Cells of the Stria Vascularis in the Guinea Pig Cochlea." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 55, no. 2, 1993, pp. 61-7.
Komune S, Nakagawa T, Hisashi K, et al. Movement of monovalent ions across the membranes of marginal cells of the stria vascularis in the guinea pig cochlea. ORL J Otorhinolaryngol Relat Spec. 1993;55(2):61-7.
Komune, S., Nakagawa, T., Hisashi, K., Kimituki, T., & Uemura, T. (1993). Movement of monovalent ions across the membranes of marginal cells of the stria vascularis in the guinea pig cochlea. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 55(2), 61-7.
Komune S, et al. Movement of Monovalent Ions Across the Membranes of Marginal Cells of the Stria Vascularis in the Guinea Pig Cochlea. ORL J Otorhinolaryngol Relat Spec. 1993 Mar-Apr;55(2):61-7. PubMed PMID: 8383309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Movement of monovalent ions across the membranes of marginal cells of the stria vascularis in the guinea pig cochlea. AU - Komune,S, AU - Nakagawa,T, AU - Hisashi,K, AU - Kimituki,T, AU - Uemura,T, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 61 EP - 7 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J Otorhinolaryngol Relat Spec VL - 55 IS - 2 N2 - The resting potential and monovalent ions in the marginal cells and scala media were measured before and 20 min after the onset of anoxia using ion-sensitive microelectrodes. The resting potential of the marginal cells decreased from 62.7 to -2.4 mV. The K+ activity decreased from 77.7 to 53.2 mEq/l, while the Na+ activity increased from 2.6 to 24.7 mEq/l. The Cl- activity did not change significantly. In the scala media, the endocochlear potential decreased rapidly from 80.9 to -28.0 mV after the onset of anoxia. The K+ activity decreased from 119.0 to 96.5 mEq/l, the Na+ activity increased from 1.3 to 9.5 mEq/l and that of Cl- decreased from 127.0 to 115.1 mEq/l. The electrochemical gradients determined for each ion based on the ionic changes in the scala media and marginal cells, suggested the existence of an Na/K pump and Na-K-2Cl cotransport at the basolateral membrane of the marginal cells, and a rheogenic K pump and Na-K-2Cl transport at the luminal membrane of the marginal cells. The Na+ and K+ must be recycled at the basolateral membrane and luminal membrane of marginal cells, respectively. SN - 0301-1569 UR - https://www.unboundmedicine.com/medline/citation/8383309/Movement_of_monovalent_ions_across_the_membranes_of_marginal_cells_of_the_stria_vascularis_in_the_guinea_pig_cochlea_ L2 - https://www.karger.com?DOI=10.1159/000276380 DB - PRIME DP - Unbound Medicine ER -