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Clinical efficacy of azithromycin in lower respiratory tract infections.
J Chemother. 1993 Feb; 5(1):32-6.JC

Abstract

A total of 51 patients with acute exacerbation of chronic bronchitis and pneumonia were enrolled: 27 treated with azithromycin (500 mg once a day for 3 days), and 24 with roxithromycin (150 mg every 12 hours for 7 days). The two regimens were equally effective, with clinical cure in 80% and 72% of patients respectively. Bacteriological eradication on day 19-23 was obtained in 7/11 cases (64%) and in 6/13 cases (46%) in the two groups, respectively. No side effects occurred in patients treated with azithromycin, while they occurred in the roxithromycin group (2 vomiting and 1 gastritis). Clinical and bacteriological efficacy, excellent tolerability, simplified dosage (single daily dose) and short-course (3 days) therapeutic regimen make azithromycin, in our experience, efficacious for the treatment of acute exacerbation of chronic bronchitis and community-acquired pneumonia.

Authors+Show Affiliations

Pneumology Division, Ospedale Maggiore, USSL 25, Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8384658

Citation

Morandini, G, et al. "Clinical Efficacy of Azithromycin in Lower Respiratory Tract Infections." Journal of Chemotherapy (Florence, Italy), vol. 5, no. 1, 1993, pp. 32-6.
Morandini G, Perduca M, Zannini G, et al. Clinical efficacy of azithromycin in lower respiratory tract infections. J Chemother. 1993;5(1):32-6.
Morandini, G., Perduca, M., Zannini, G., Foschino, M. P., Miragliotta, G., & Carnimeo, N. S. (1993). Clinical efficacy of azithromycin in lower respiratory tract infections. Journal of Chemotherapy (Florence, Italy), 5(1), 32-6.
Morandini G, et al. Clinical Efficacy of Azithromycin in Lower Respiratory Tract Infections. J Chemother. 1993;5(1):32-6. PubMed PMID: 8384658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical efficacy of azithromycin in lower respiratory tract infections. AU - Morandini,G, AU - Perduca,M, AU - Zannini,G, AU - Foschino,M P, AU - Miragliotta,G, AU - Carnimeo,N S, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 32 EP - 6 JF - Journal of chemotherapy (Florence, Italy) JO - J Chemother VL - 5 IS - 1 N2 - A total of 51 patients with acute exacerbation of chronic bronchitis and pneumonia were enrolled: 27 treated with azithromycin (500 mg once a day for 3 days), and 24 with roxithromycin (150 mg every 12 hours for 7 days). The two regimens were equally effective, with clinical cure in 80% and 72% of patients respectively. Bacteriological eradication on day 19-23 was obtained in 7/11 cases (64%) and in 6/13 cases (46%) in the two groups, respectively. No side effects occurred in patients treated with azithromycin, while they occurred in the roxithromycin group (2 vomiting and 1 gastritis). Clinical and bacteriological efficacy, excellent tolerability, simplified dosage (single daily dose) and short-course (3 days) therapeutic regimen make azithromycin, in our experience, efficacious for the treatment of acute exacerbation of chronic bronchitis and community-acquired pneumonia. SN - 1120-009X UR - https://www.unboundmedicine.com/medline/citation/8384658/Clinical_efficacy_of_azithromycin_in_lower_respiratory_tract_infections_ L2 - https://medlineplus.gov/acutebronchitis.html DB - PRIME DP - Unbound Medicine ER -