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Effects of acute acid loading on parathyroid hormone secretion and on urinary calcium and cAMP excretion in the growing lamb.
Exp Physiol. 1993 Mar; 78(2):157-63.EP

Abstract

Growing lambs fed a diet containing NaHCO3 were made acidotic by intravenously infusing HCl at the rate of 1 mmol/min over a 4 h period. Acid infusion led to a fall in blood and urine pH and a prompt increase in urinary Ca excretion. This in turn led to a fall in plasma Ca concentration and a rise in parathyroid hormone (PTH) levels. Urinary cAMP excretion was unaffected by acid infusion. In separate experiments lambs made acidotic by feeding a diet containing NH4Cl were given infusions of PTH at the rate of 1 microgram/h. Infusion of the hormone was accompanied by a rise in plasma Ca and an increase rather than a decrease in urinary Ca excretion and no change in urinary cAMP excretion. These results point to the kidney as the primary site of response to acid loading in the lamb, a failure to reabsorb Ca in these conditions necessitating the release of PTH and an increase in bone resorption in order to maintain normal plasma Ca levels.

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Authors+Show Affiliations

Scott D
Rowett Research Institute, Bucksburn, Aberdeen.
Loveridge N
No affiliation info available
Abu Damir H
No affiliation info available
Buchan W
No affiliation info available
Milne J
No affiliation info available

MeSH

AcidosisAnimalsBone ResorptionCalciumCyclic AMPFemaleKidneyParathyroid HormonePeptide FragmentsSheepTeriparatide

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8385960

Citation

Scott, D, et al. "Effects of Acute Acid Loading On Parathyroid Hormone Secretion and On Urinary Calcium and cAMP Excretion in the Growing Lamb." Experimental Physiology, vol. 78, no. 2, 1993, pp. 157-63.
Scott D, Loveridge N, Abu Damir H, et al. Effects of acute acid loading on parathyroid hormone secretion and on urinary calcium and cAMP excretion in the growing lamb. Exp Physiol. 1993;78(2):157-63.
Scott, D., Loveridge, N., Abu Damir, H., Buchan, W., & Milne, J. (1993). Effects of acute acid loading on parathyroid hormone secretion and on urinary calcium and cAMP excretion in the growing lamb. Experimental Physiology, 78(2), 157-63.
Scott D, et al. Effects of Acute Acid Loading On Parathyroid Hormone Secretion and On Urinary Calcium and cAMP Excretion in the Growing Lamb. Exp Physiol. 1993;78(2):157-63. PubMed PMID: 8385960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute acid loading on parathyroid hormone secretion and on urinary calcium and cAMP excretion in the growing lamb. AU - Scott,D, AU - Loveridge,N, AU - Abu Damir,H, AU - Buchan,W, AU - Milne,J, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 157 EP - 63 JF - Experimental physiology JO - Exp Physiol VL - 78 IS - 2 N2 - Growing lambs fed a diet containing NaHCO3 were made acidotic by intravenously infusing HCl at the rate of 1 mmol/min over a 4 h period. Acid infusion led to a fall in blood and urine pH and a prompt increase in urinary Ca excretion. This in turn led to a fall in plasma Ca concentration and a rise in parathyroid hormone (PTH) levels. Urinary cAMP excretion was unaffected by acid infusion. In separate experiments lambs made acidotic by feeding a diet containing NH4Cl were given infusions of PTH at the rate of 1 microgram/h. Infusion of the hormone was accompanied by a rise in plasma Ca and an increase rather than a decrease in urinary Ca excretion and no change in urinary cAMP excretion. These results point to the kidney as the primary site of response to acid loading in the lamb, a failure to reabsorb Ca in these conditions necessitating the release of PTH and an increase in bone resorption in order to maintain normal plasma Ca levels. SN - 0958-0670 UR - https://www.unboundmedicine.com/medline/citation/8385960/Effects_of_acute_acid_loading_on_parathyroid_hormone_secretion_and_on_urinary_calcium_and_cAMP_excretion_in_the_growing_lamb_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0958-0670&date=1993&volume=78&issue=2&spage=157 DB - PRIME DP - Unbound Medicine ER -