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[Acrodystrophic neuropathy in an alcoholic].
No To Shinkei. 1993 Jan; 45(1):71-5.NT

Abstract

The patient was a 48-year-old alcoholic man with no contributory family history. At age 36 he had developed sensory dominant polyneuropathy with highly impaired temperature sensation and deep sensation in the lower extremities, recurrent ulcers of the toes, and sexual impotence. A sural nerve biopsy at this time revealed marked loss of myelinated fibers with relative preservation of the population of unmyelinated fibers. Subsequently, he developed muscle atrophy of the lower thighs, urinary incontinence, and Wernicke's encephalopathy, and became non-ambulatory at age 44. The peripheral nerve conduction findings suggested predominantly axonal degeneration. The entire course was characterized by alternative progression and partial recovery influenced by his alcohol intake and nutritional state. Alcoholic neuropathy is a major cause of solitary acrodystrophic neuropathy (ADN). Manifestations of autonomic and motor neuropathy are more marked in alcoholic ADN than in HSAN-I, and central nervous system involvement is the hallmark of alcoholic ADN. In the treatment of patients with alcoholic ADN, attention should be paid to diabetes mellitus, malnutritional state, and vitamin deficiency, which frequently complicate alcoholism.

Authors+Show Affiliations

Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

8386536

Citation

Yamamura, Y, et al. "[Acrodystrophic Neuropathy in an Alcoholic]." No to Shinkei = Brain and Nerve, vol. 45, no. 1, 1993, pp. 71-5.
Yamamura Y, Hironaka M, Shimoyama M, et al. [Acrodystrophic neuropathy in an alcoholic]. No To Shinkei. 1993;45(1):71-5.
Yamamura, Y., Hironaka, M., Shimoyama, M., Toyota, Y., Kurokawa, M., Kohriyama, T., & Nakamura, S. (1993). [Acrodystrophic neuropathy in an alcoholic]. No to Shinkei = Brain and Nerve, 45(1), 71-5.
Yamamura Y, et al. [Acrodystrophic Neuropathy in an Alcoholic]. No To Shinkei. 1993;45(1):71-5. PubMed PMID: 8386536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acrodystrophic neuropathy in an alcoholic]. AU - Yamamura,Y, AU - Hironaka,M, AU - Shimoyama,M, AU - Toyota,Y, AU - Kurokawa,M, AU - Kohriyama,T, AU - Nakamura,S, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 71 EP - 5 JF - No to shinkei = Brain and nerve JO - No To Shinkei VL - 45 IS - 1 N2 - The patient was a 48-year-old alcoholic man with no contributory family history. At age 36 he had developed sensory dominant polyneuropathy with highly impaired temperature sensation and deep sensation in the lower extremities, recurrent ulcers of the toes, and sexual impotence. A sural nerve biopsy at this time revealed marked loss of myelinated fibers with relative preservation of the population of unmyelinated fibers. Subsequently, he developed muscle atrophy of the lower thighs, urinary incontinence, and Wernicke's encephalopathy, and became non-ambulatory at age 44. The peripheral nerve conduction findings suggested predominantly axonal degeneration. The entire course was characterized by alternative progression and partial recovery influenced by his alcohol intake and nutritional state. Alcoholic neuropathy is a major cause of solitary acrodystrophic neuropathy (ADN). Manifestations of autonomic and motor neuropathy are more marked in alcoholic ADN than in HSAN-I, and central nervous system involvement is the hallmark of alcoholic ADN. In the treatment of patients with alcoholic ADN, attention should be paid to diabetes mellitus, malnutritional state, and vitamin deficiency, which frequently complicate alcoholism. SN - 0006-8969 UR - https://www.unboundmedicine.com/medline/citation/8386536/[Acrodystrophic_neuropathy_in_an_alcoholic]_ L2 - https://medlineplus.gov/alcoholusedisorderaud.html DB - PRIME DP - Unbound Medicine ER -