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Effects of post-training administration of (-)-baclofen and chlordiazepoxide on memory retention in ICRC Swiss mice: interactions with GABAA and GABAB receptor antagonists.
Pharmacol Toxicol. 1993 Mar; 72(3):159-62.PT

Abstract

The effects of post-training administration of chlordiazepoxide and (-)-baclofen on memory retention was studied in ICRC Swiss mice by measuring the retest stepdown latency 24 hr after foot-shock in a passive avoidance task. Chlordiazepoxide 20 mg/kg impaired memory retention and a similar effect was produced by 10 mg/kg of diazepam. The effect of chlordiazepoxide was antagonised when combined with picrotoxin but not by the addition of a specific GABAB antagonist CGP 35348. The effect of chlordiazepoxide on memory retention seems to be mediated by action at the GABAA-benzodiazepine receptor complex. (-) Baclofen, the active isomer of the GABAB agonist enhanced memory in ICRC mice and this effect was antagonised by CGP 35348 at a dose of 10 mg/kg. The inactive isomer of baclofen, (+)-baclofen did not produce any effect. This indicates that GABAB receptors contribute to the effects of (-)-baclofen on memory.

Authors+Show Affiliations

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8390652

Citation

Saha, N, et al. "Effects of Post-training Administration of (-)-baclofen and Chlordiazepoxide On Memory Retention in ICRC Swiss Mice: Interactions With GABAA and GABAB Receptor Antagonists." Pharmacology & Toxicology, vol. 72, no. 3, 1993, pp. 159-62.
Saha N, Chugh Y, Sankaranaryanan A, et al. Effects of post-training administration of (-)-baclofen and chlordiazepoxide on memory retention in ICRC Swiss mice: interactions with GABAA and GABAB receptor antagonists. Pharmacol Toxicol. 1993;72(3):159-62.
Saha, N., Chugh, Y., Sankaranaryanan, A., & Sharma, P. L. (1993). Effects of post-training administration of (-)-baclofen and chlordiazepoxide on memory retention in ICRC Swiss mice: interactions with GABAA and GABAB receptor antagonists. Pharmacology & Toxicology, 72(3), 159-62.
Saha N, et al. Effects of Post-training Administration of (-)-baclofen and Chlordiazepoxide On Memory Retention in ICRC Swiss Mice: Interactions With GABAA and GABAB Receptor Antagonists. Pharmacol Toxicol. 1993;72(3):159-62. PubMed PMID: 8390652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of post-training administration of (-)-baclofen and chlordiazepoxide on memory retention in ICRC Swiss mice: interactions with GABAA and GABAB receptor antagonists. AU - Saha,N, AU - Chugh,Y, AU - Sankaranaryanan,A, AU - Sharma,P L, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 159 EP - 62 JF - Pharmacology & toxicology JO - Pharmacol Toxicol VL - 72 IS - 3 N2 - The effects of post-training administration of chlordiazepoxide and (-)-baclofen on memory retention was studied in ICRC Swiss mice by measuring the retest stepdown latency 24 hr after foot-shock in a passive avoidance task. Chlordiazepoxide 20 mg/kg impaired memory retention and a similar effect was produced by 10 mg/kg of diazepam. The effect of chlordiazepoxide was antagonised when combined with picrotoxin but not by the addition of a specific GABAB antagonist CGP 35348. The effect of chlordiazepoxide on memory retention seems to be mediated by action at the GABAA-benzodiazepine receptor complex. (-) Baclofen, the active isomer of the GABAB agonist enhanced memory in ICRC mice and this effect was antagonised by CGP 35348 at a dose of 10 mg/kg. The inactive isomer of baclofen, (+)-baclofen did not produce any effect. This indicates that GABAB receptors contribute to the effects of (-)-baclofen on memory. SN - 0901-9928 UR - https://www.unboundmedicine.com/medline/citation/8390652/Effects_of_post_training_administration_of_____baclofen_and_chlordiazepoxide_on_memory_retention_in_ICRC_Swiss_mice:_interactions_with_GABAA_and_GABAB_receptor_antagonists_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0901-9928&date=1993&volume=72&issue=3&spage=159 DB - PRIME DP - Unbound Medicine ER -