Tags

Type your tag names separated by a space and hit enter

(+/-)Baclofen sensitive scopolamine-induced short-term memory deficits in mice.
Indian J Exp Biol. 1993 Apr; 31(4):348-52.IJ

Abstract

Possible involvement of GABA receptor systems in scopolamine-induced short-term memory deficits was investigated using latency of mice to reach shock-free zone (SFZ) and number of mistakes (descents) the animal made in 15 min as parameters for acquisition and retention of memory in passive avoidance paradigm. Atropine (1-5 mg/kg), scopolamine (0.1-0.5 mg/kg) but not pirenzepine (5-20 mg/kg) caused disruption of memory. GABA (50, 75 and 100 mg/kg) showed retention enhancing effects in scopolamine-treated and untreated animals but GABA agonist progabide (5-20 mg/kg) did not affect any of the parameter significantly. GABAA agonist, muscimol (0.05 and 0.1 mg/kg) and GABAB agonist, (+/-)baclofen (0.25, 0.5 and 1 mg/kg) and (-)baclofen (0.25 and 0.5 mg/kg) also displayed memory enhancing action. Whereas, GABAA antagonist, bicuculline produced hind limb rigidity, GABAB antagonist, CGP 35348 did not show any effect per se, but reversed the (+/-)baclofen-induced delay in latency, without affecting retention enhancing action of (+/-)baclofen. Combined administration of subeffective dose of GABA (50 mg/kg) and (+/-)baclofen (0.25 mg/kg), showed a significant improvement in acquisition and retention. However, the effect of GABA (100 mg/kg) on acquisition was reversed by bicuculline (2 mg/kg) and by CGP 35348 (100 mg/kg) while improving retention. The present study extends support to the cholinergic concept in cognitive performance and provide an evidence for the influence of GABAergic (particularly GABAB) modulation in scopolamine-induced learning and memory deficits in mice.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8395465

Citation

Sharma, A C., and S K. Kulkarni. "(+/-)Baclofen Sensitive Scopolamine-induced Short-term Memory Deficits in Mice." Indian Journal of Experimental Biology, vol. 31, no. 4, 1993, pp. 348-52.
Sharma AC, Kulkarni SK. (+/-)Baclofen sensitive scopolamine-induced short-term memory deficits in mice. Indian J Exp Biol. 1993;31(4):348-52.
Sharma, A. C., & Kulkarni, S. K. (1993). (+/-)Baclofen sensitive scopolamine-induced short-term memory deficits in mice. Indian Journal of Experimental Biology, 31(4), 348-52.
Sharma AC, Kulkarni SK. (+/-)Baclofen Sensitive Scopolamine-induced Short-term Memory Deficits in Mice. Indian J Exp Biol. 1993;31(4):348-52. PubMed PMID: 8395465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - (+/-)Baclofen sensitive scopolamine-induced short-term memory deficits in mice. AU - Sharma,A C, AU - Kulkarni,S K, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 348 EP - 52 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 31 IS - 4 N2 - Possible involvement of GABA receptor systems in scopolamine-induced short-term memory deficits was investigated using latency of mice to reach shock-free zone (SFZ) and number of mistakes (descents) the animal made in 15 min as parameters for acquisition and retention of memory in passive avoidance paradigm. Atropine (1-5 mg/kg), scopolamine (0.1-0.5 mg/kg) but not pirenzepine (5-20 mg/kg) caused disruption of memory. GABA (50, 75 and 100 mg/kg) showed retention enhancing effects in scopolamine-treated and untreated animals but GABA agonist progabide (5-20 mg/kg) did not affect any of the parameter significantly. GABAA agonist, muscimol (0.05 and 0.1 mg/kg) and GABAB agonist, (+/-)baclofen (0.25, 0.5 and 1 mg/kg) and (-)baclofen (0.25 and 0.5 mg/kg) also displayed memory enhancing action. Whereas, GABAA antagonist, bicuculline produced hind limb rigidity, GABAB antagonist, CGP 35348 did not show any effect per se, but reversed the (+/-)baclofen-induced delay in latency, without affecting retention enhancing action of (+/-)baclofen. Combined administration of subeffective dose of GABA (50 mg/kg) and (+/-)baclofen (0.25 mg/kg), showed a significant improvement in acquisition and retention. However, the effect of GABA (100 mg/kg) on acquisition was reversed by bicuculline (2 mg/kg) and by CGP 35348 (100 mg/kg) while improving retention. The present study extends support to the cholinergic concept in cognitive performance and provide an evidence for the influence of GABAergic (particularly GABAB) modulation in scopolamine-induced learning and memory deficits in mice. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/8395465/_+/__Baclofen_sensitive_scopolamine_induced_short_term_memory_deficits_in_mice_ DB - PRIME DP - Unbound Medicine ER -