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Adoptive transfer of experimental allergic encephalomyelitis: incubation of rat spleen cells with specific antigen.
J Immunol. 1979 Feb; 122(2):494-6.JI

Abstract

Spleen cells from myelin basic protein (BP)-sensitized donor rats appear to be incapable of adoptively transferring experimental allergic encephalomyelitis (EAE) directly to normal recipients. It has been reported that in vitro incubation with concanavalin A (Con A) activates rat spleen cells so that they are capable of transferring EAE. We report here that incubation with specific antigen, BP, also permits transfer of disease with spleen cells. Data are presented in which activation of EAE spleen cells by Con A is compared with activation by BP. Cellular proliferation does not appear to be necessary for in vitro activation with specific antigen.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

84024

Citation

Richert, J R., et al. "Adoptive Transfer of Experimental Allergic Encephalomyelitis: Incubation of Rat Spleen Cells With Specific Antigen." Journal of Immunology (Baltimore, Md. : 1950), vol. 122, no. 2, 1979, pp. 494-6.
Richert JR, Driscoll BF, Kies MW, et al. Adoptive transfer of experimental allergic encephalomyelitis: incubation of rat spleen cells with specific antigen. J Immunol. 1979;122(2):494-6.
Richert, J. R., Driscoll, B. F., Kies, M. W., & Alvord, E. C. (1979). Adoptive transfer of experimental allergic encephalomyelitis: incubation of rat spleen cells with specific antigen. Journal of Immunology (Baltimore, Md. : 1950), 122(2), 494-6.
Richert JR, et al. Adoptive Transfer of Experimental Allergic Encephalomyelitis: Incubation of Rat Spleen Cells With Specific Antigen. J Immunol. 1979;122(2):494-6. PubMed PMID: 84024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adoptive transfer of experimental allergic encephalomyelitis: incubation of rat spleen cells with specific antigen. AU - Richert,J R, AU - Driscoll,B F, AU - Kies,M W, AU - Alvord,E C,Jr PY - 1979/2/1/pubmed PY - 2001/3/28/medline PY - 1979/2/1/entrez SP - 494 EP - 6 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 122 IS - 2 N2 - Spleen cells from myelin basic protein (BP)-sensitized donor rats appear to be incapable of adoptively transferring experimental allergic encephalomyelitis (EAE) directly to normal recipients. It has been reported that in vitro incubation with concanavalin A (Con A) activates rat spleen cells so that they are capable of transferring EAE. We report here that incubation with specific antigen, BP, also permits transfer of disease with spleen cells. Data are presented in which activation of EAE spleen cells by Con A is compared with activation by BP. Cellular proliferation does not appear to be necessary for in vitro activation with specific antigen. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/84024/Adoptive_transfer_of_experimental_allergic_encephalomyelitis:_incubation_of_rat_spleen_cells_with_specific_antigen_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=84024 DB - PRIME DP - Unbound Medicine ER -