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Galactorrhea: a study of 235 cases, including 48 with pituitary tumors.
N Engl J Med. 1977 Mar 17; 296(11):589-600.NEJM

Abstract

An analysis of 235 patients with galactorrhea (5.5 per cent males) showed that 20 per cent of all patients, and 34 per cent of women with associated amenorrhea, had radiologically evident pituitary tumors; these patients had the highest serum prolactin concentrations. The largest single group (32 per cent) consisted of women with idiopathic galactorrhea without amenorrhea; prolactin was normal in 86 per cent of these cases. Five patients had the empty-sella syndrome. Prolactin response was tested in selected patients by thyrotropin-releasing hormone, chlorpromazine, L-dopa, 24-hour sampling and other means. Tests with thyrotropin-releasing hormone were most useful in identifying patients with pituitary tumors. Surgery and radiotherapy lowered prolactin to a similar degree in patients with tumor, but galactorrhea, and amenorrhea often persisted after treatment. The ergot derivatives, bromergocryptine and lergotrile mesylate, lowered prolactin in all 18 patients with idiopathic hyperprolactinemia or pituitary tumor, stopped galactorrhea in over 50 per cent, restored menses in over 70 per cent, and allowed pregnancy in three.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

840242

Citation

Kleinberg, D L., et al. "Galactorrhea: a Study of 235 Cases, Including 48 With Pituitary Tumors." The New England Journal of Medicine, vol. 296, no. 11, 1977, pp. 589-600.
Kleinberg DL, Noel GL, Frantz AG. Galactorrhea: a study of 235 cases, including 48 with pituitary tumors. N Engl J Med. 1977;296(11):589-600.
Kleinberg, D. L., Noel, G. L., & Frantz, A. G. (1977). Galactorrhea: a study of 235 cases, including 48 with pituitary tumors. The New England Journal of Medicine, 296(11), 589-600.
Kleinberg DL, Noel GL, Frantz AG. Galactorrhea: a Study of 235 Cases, Including 48 With Pituitary Tumors. N Engl J Med. 1977 Mar 17;296(11):589-600. PubMed PMID: 840242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactorrhea: a study of 235 cases, including 48 with pituitary tumors. AU - Kleinberg,D L, AU - Noel,G L, AU - Frantz,A G, PY - 1977/3/17/pubmed PY - 1977/3/17/medline PY - 1977/3/17/entrez KW - Age Factors KW - Amenorrhea KW - Biology KW - Breast Feeding KW - Cancer--etiology KW - Central Nervous System KW - Central Nervous System Effects KW - Diseases KW - Endocrine System KW - Galactorrhea KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Men KW - Menstruation Disorders KW - Neoplasms KW - Oral Contraceptives KW - Physiology KW - Pituitary Gland KW - Pituitary Hormones KW - Population Characteristics KW - Prolactin--analysis KW - Puerperal Disorders KW - Thyroid Effects KW - Treatment KW - Women SP - 589 EP - 600 JF - The New England journal of medicine JO - N Engl J Med VL - 296 IS - 11 N2 - An analysis of 235 patients with galactorrhea (5.5 per cent males) showed that 20 per cent of all patients, and 34 per cent of women with associated amenorrhea, had radiologically evident pituitary tumors; these patients had the highest serum prolactin concentrations. The largest single group (32 per cent) consisted of women with idiopathic galactorrhea without amenorrhea; prolactin was normal in 86 per cent of these cases. Five patients had the empty-sella syndrome. Prolactin response was tested in selected patients by thyrotropin-releasing hormone, chlorpromazine, L-dopa, 24-hour sampling and other means. Tests with thyrotropin-releasing hormone were most useful in identifying patients with pituitary tumors. Surgery and radiotherapy lowered prolactin to a similar degree in patients with tumor, but galactorrhea, and amenorrhea often persisted after treatment. The ergot derivatives, bromergocryptine and lergotrile mesylate, lowered prolactin in all 18 patients with idiopathic hyperprolactinemia or pituitary tumor, stopped galactorrhea in over 50 per cent, restored menses in over 70 per cent, and allowed pregnancy in three. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/840242/Galactorrhea:_a_study_of_235_cases_including_48_with_pituitary_tumors_ L2 - https://www.nejm.org/doi/10.1056/NEJM197703172961103?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -