Tags

Type your tag names separated by a space and hit enter

Lipid-rich residual bodies and cathepsin D in the human uterus: ultrastructural and quantitative comparison between normal myometrium and leiomyoma.
J Submicrosc Cytol Pathol. 1993 Jul; 25(3):437-47.JS

Abstract

The lipid-rich residual bodies (LRRB) (Eyden et al., 1991) in human myometrium and uterine leiomyoma cells, have a distinctive ultrastructure characterised by a rich lipid content. To evaluate the biological or pathological significance in detail, normal myometrium and uterine leiomyoma from 30 human cases were studied by conventional histological, histochemical, immunohistochemical and electron microscopic methods. The study included a quantitative analysis of LRRBs of 3 premenarchic cases, 19 cases having a menstrual cycle, and 8 cases in menopause, in addition to 20 patients with histologically conventional leiomyoma larger than 3 cm in diameter. The study revealed the following findings: 1) immunohistochemical distribution of cathepsin D in the LRRB; 2) histochemical demonstration of neutral fat as the main content of LRRB; 3) statistically significant decrease in the distribution of LRRB in leiomyoma tissue compared with normal myometrium; 4) an absence or minimal distribution of LRRB in premenarchic myometrium; 5) a moderately significant correlation between the frequency of LRRB and patient's age. The distribution of cathepsin D within LRRB and the differential expression of LRRBs in the various smooth muscle cell tissues of the uterus suggest a possible role of ovarian hormones in the genesis of LRRBs which may function in the intra-lysosomal degradation of organelles produced during hormonal cycling.

Authors+Show Affiliations

Yamazaki K
Department of Pathology, Tokyo Teishin Hospital, Japan.
Yakumaru K
No affiliation info available
Eyden BP
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overAgingCathepsin DChildFemaleHumansImmunohistochemistryInclusion BodiesInfant, NewbornLeiomyomaLipid MetabolismLipidsMenopauseMenstrual CycleMicroscopy, ElectronMiddle AgedMyometriumOrganellesUterine NeoplasmsUterus

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8402543

Citation

Yamazaki, K, et al. "Lipid-rich Residual Bodies and Cathepsin D in the Human Uterus: Ultrastructural and Quantitative Comparison Between Normal Myometrium and Leiomyoma." Journal of Submicroscopic Cytology and Pathology, vol. 25, no. 3, 1993, pp. 437-47.
Yamazaki K, Yakumaru K, Eyden BP. Lipid-rich residual bodies and cathepsin D in the human uterus: ultrastructural and quantitative comparison between normal myometrium and leiomyoma. J Submicrosc Cytol Pathol. 1993;25(3):437-47.
Yamazaki, K., Yakumaru, K., & Eyden, B. P. (1993). Lipid-rich residual bodies and cathepsin D in the human uterus: ultrastructural and quantitative comparison between normal myometrium and leiomyoma. Journal of Submicroscopic Cytology and Pathology, 25(3), 437-47.
Yamazaki K, Yakumaru K, Eyden BP. Lipid-rich Residual Bodies and Cathepsin D in the Human Uterus: Ultrastructural and Quantitative Comparison Between Normal Myometrium and Leiomyoma. J Submicrosc Cytol Pathol. 1993;25(3):437-47. PubMed PMID: 8402543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid-rich residual bodies and cathepsin D in the human uterus: ultrastructural and quantitative comparison between normal myometrium and leiomyoma. AU - Yamazaki,K, AU - Yakumaru,K, AU - Eyden,B P, PY - 1993/7/1/pubmed PY - 1993/7/1/medline PY - 1993/7/1/entrez SP - 437 EP - 47 JF - Journal of submicroscopic cytology and pathology JO - J Submicrosc Cytol Pathol VL - 25 IS - 3 N2 - The lipid-rich residual bodies (LRRB) (Eyden et al., 1991) in human myometrium and uterine leiomyoma cells, have a distinctive ultrastructure characterised by a rich lipid content. To evaluate the biological or pathological significance in detail, normal myometrium and uterine leiomyoma from 30 human cases were studied by conventional histological, histochemical, immunohistochemical and electron microscopic methods. The study included a quantitative analysis of LRRBs of 3 premenarchic cases, 19 cases having a menstrual cycle, and 8 cases in menopause, in addition to 20 patients with histologically conventional leiomyoma larger than 3 cm in diameter. The study revealed the following findings: 1) immunohistochemical distribution of cathepsin D in the LRRB; 2) histochemical demonstration of neutral fat as the main content of LRRB; 3) statistically significant decrease in the distribution of LRRB in leiomyoma tissue compared with normal myometrium; 4) an absence or minimal distribution of LRRB in premenarchic myometrium; 5) a moderately significant correlation between the frequency of LRRB and patient's age. The distribution of cathepsin D within LRRB and the differential expression of LRRBs in the various smooth muscle cell tissues of the uterus suggest a possible role of ovarian hormones in the genesis of LRRBs which may function in the intra-lysosomal degradation of organelles produced during hormonal cycling. SN - 1122-9497 UR - https://www.unboundmedicine.com/medline/citation/8402543/Lipid_rich_residual_bodies_and_cathepsin_D_in_the_human_uterus:_ultrastructural_and_quantitative_comparison_between_normal_myometrium_and_leiomyoma_ L2 - https://medlineplus.gov/uterinefibroids.html DB - PRIME DP - Unbound Medicine ER -