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Cardioprotective properties of O-(beta-hydroxyethyl)-rutosides in doxorubicin-pretreated BALB/c mice.
Cancer Res 1993; 53(19):4603-7CR

Abstract

Chronic doxorubicin-induced cardiotoxicity is believed to be caused by the formation of oxygen free radicals. Thus O-(beta-hydroxyethyl)-rutosides, a standardized flavonoid mixture (Venoruton) with iron chelating and radical scavenging activity, might provide protection. Therefore, we investigated the (cardio)protective effect of Venoruton (1.5 g/kg injected i.p. on days 1-5, 8-12, 15-19, and 22-26) in BALB/c mice treated with doxorubicin (4 mg/kg injected i.v. on days 1, 8, 15, and 22) compared with mice treated with doxorubicin alone. Saline-treated animals served as controls. No mortality was encountered in either of the groups; weight gain data suggest little general toxicity of this dose schedule. The basal frequency of the isolated right atria was increased in doxorubicin-pretreated animals as compared to control animals (468 +/- 22 and 366 +/- 20 beats/min, respectively). Venoruton coadministration diminished this increase (373 +/- 17 beats/min). The -log of the concentration giving 50% effect of l-isoprenaline on the right atrium was changed after doxorubicin pretreatment (8.33 +/- 0.04 versus 8.86 +/- 0.06 for control animals). Venoruton coadministration resulted in a smaller shift in the -log of the concentration giving 50% effect (8.51 +/- 0.10) than with doxorubicin alone. The extent of cardiotoxicity found in the functional studies was confirmed by histological scoring of heart ventricle damage. It can be concluded that Venoruton has the potential to protect against doxorubicin-induced cardiotoxicity.

Authors+Show Affiliations

Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8402634

Citation

van Acker, S A., et al. "Cardioprotective Properties of O-(beta-hydroxyethyl)-rutosides in Doxorubicin-pretreated BALB/c Mice." Cancer Research, vol. 53, no. 19, 1993, pp. 4603-7.
van Acker SA, Voest EE, Beems DB, et al. Cardioprotective properties of O-(beta-hydroxyethyl)-rutosides in doxorubicin-pretreated BALB/c mice. Cancer Res. 1993;53(19):4603-7.
van Acker, S. A., Voest, E. E., Beems, D. B., Madhuizen, H. T., de Jong, J., Bast, A., & van der Vijgh, W. J. (1993). Cardioprotective properties of O-(beta-hydroxyethyl)-rutosides in doxorubicin-pretreated BALB/c mice. Cancer Research, 53(19), pp. 4603-7.
van Acker SA, et al. Cardioprotective Properties of O-(beta-hydroxyethyl)-rutosides in Doxorubicin-pretreated BALB/c Mice. Cancer Res. 1993 Oct 1;53(19):4603-7. PubMed PMID: 8402634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardioprotective properties of O-(beta-hydroxyethyl)-rutosides in doxorubicin-pretreated BALB/c mice. AU - van Acker,S A, AU - Voest,E E, AU - Beems,D B, AU - Madhuizen,H T, AU - de Jong,J, AU - Bast,A, AU - van der Vijgh,W J, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 4603 EP - 7 JF - Cancer research JO - Cancer Res. VL - 53 IS - 19 N2 - Chronic doxorubicin-induced cardiotoxicity is believed to be caused by the formation of oxygen free radicals. Thus O-(beta-hydroxyethyl)-rutosides, a standardized flavonoid mixture (Venoruton) with iron chelating and radical scavenging activity, might provide protection. Therefore, we investigated the (cardio)protective effect of Venoruton (1.5 g/kg injected i.p. on days 1-5, 8-12, 15-19, and 22-26) in BALB/c mice treated with doxorubicin (4 mg/kg injected i.v. on days 1, 8, 15, and 22) compared with mice treated with doxorubicin alone. Saline-treated animals served as controls. No mortality was encountered in either of the groups; weight gain data suggest little general toxicity of this dose schedule. The basal frequency of the isolated right atria was increased in doxorubicin-pretreated animals as compared to control animals (468 +/- 22 and 366 +/- 20 beats/min, respectively). Venoruton coadministration diminished this increase (373 +/- 17 beats/min). The -log of the concentration giving 50% effect of l-isoprenaline on the right atrium was changed after doxorubicin pretreatment (8.33 +/- 0.04 versus 8.86 +/- 0.06 for control animals). Venoruton coadministration resulted in a smaller shift in the -log of the concentration giving 50% effect (8.51 +/- 0.10) than with doxorubicin alone. The extent of cardiotoxicity found in the functional studies was confirmed by histological scoring of heart ventricle damage. It can be concluded that Venoruton has the potential to protect against doxorubicin-induced cardiotoxicity. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/8402634/Cardioprotective_properties_of_O__beta_hydroxyethyl__rutosides_in_doxorubicin_pretreated_BALB/c_mice_ L2 - http://www.informatics.jax.org/reference/8402634 DB - PRIME DP - Unbound Medicine ER -