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Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction.
Gastroenterology 1993; 105(4):1200-8G

Abstract

BACKGROUND

Arachidonic acid (AA) and hydrophobic bile salts (BS) stimulate gallbladder mucin (GBM) secretion, which is thought to be an essential step in gallstone pathogenesis. The present study was performed to evaluate the relationship between AA, BS, and GBM in patients who develop gallstones following weight reduction.

METHODS

Eleven patients who underwent gastric bypass, developed symptomatic gallstones, and then underwent cholecystectomy were evaluated. Gallbladder bile was obtained for analysis during each procedure. Matched patients who did not develop gallstones following gastric bypass served as controls.

RESULTS

GBM increased in every patient who developed stones (mean increase: 5000%). The largest increase was observed soon after gastric bypass, and this declined curvilinearly with time. Gallbladder bile cholesterol was initially elevated but then rapidly declined before increasing back to pregastric bypass levels after weight loss was complete. No significant changes in phosphatidylcholine molecular species (including AA) or BS composition were observed following weight reduction. Concentrations of cholesterol, phospholipids, and changes in [AA] over time were each a linear function of [BS]. No relationship between GBM and any of these bile constituents was apparent.

CONCLUSIONS

These observations strongly suggest that increases in GBM, which occur with gallstone formation in humans, are not the result of alterations in biliary AA or BS composition.

Authors+Show Affiliations

Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8405867

Citation

Shiffman, M L., et al. "Gallbladder Mucin, Arachidonic Acid, and Bile Lipids in Patients Who Develop Gallstones During Weight Reduction." Gastroenterology, vol. 105, no. 4, 1993, pp. 1200-8.
Shiffman ML, Shamburek RD, Schwartz CC, et al. Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology. 1993;105(4):1200-8.
Shiffman, M. L., Shamburek, R. D., Schwartz, C. C., Sugerman, H. J., Kellum, J. M., & Moore, E. W. (1993). Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology, 105(4), pp. 1200-8.
Shiffman ML, et al. Gallbladder Mucin, Arachidonic Acid, and Bile Lipids in Patients Who Develop Gallstones During Weight Reduction. Gastroenterology. 1993;105(4):1200-8. PubMed PMID: 8405867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. AU - Shiffman,M L, AU - Shamburek,R D, AU - Schwartz,C C, AU - Sugerman,H J, AU - Kellum,J M, AU - Moore,E W, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 1200 EP - 8 JF - Gastroenterology JO - Gastroenterology VL - 105 IS - 4 N2 - BACKGROUND: Arachidonic acid (AA) and hydrophobic bile salts (BS) stimulate gallbladder mucin (GBM) secretion, which is thought to be an essential step in gallstone pathogenesis. The present study was performed to evaluate the relationship between AA, BS, and GBM in patients who develop gallstones following weight reduction. METHODS: Eleven patients who underwent gastric bypass, developed symptomatic gallstones, and then underwent cholecystectomy were evaluated. Gallbladder bile was obtained for analysis during each procedure. Matched patients who did not develop gallstones following gastric bypass served as controls. RESULTS: GBM increased in every patient who developed stones (mean increase: 5000%). The largest increase was observed soon after gastric bypass, and this declined curvilinearly with time. Gallbladder bile cholesterol was initially elevated but then rapidly declined before increasing back to pregastric bypass levels after weight loss was complete. No significant changes in phosphatidylcholine molecular species (including AA) or BS composition were observed following weight reduction. Concentrations of cholesterol, phospholipids, and changes in [AA] over time were each a linear function of [BS]. No relationship between GBM and any of these bile constituents was apparent. CONCLUSIONS: These observations strongly suggest that increases in GBM, which occur with gallstone formation in humans, are not the result of alterations in biliary AA or BS composition. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/8405867/Gallbladder_mucin_arachidonic_acid_and_bile_lipids_in_patients_who_develop_gallstones_during_weight_reduction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0016-5085(93)90968-I DB - PRIME DP - Unbound Medicine ER -