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Adenosquamous carcinoma of the cervix: prognosis in early stage disease treated by radical hysterectomy.
Gynecol Oncol. 1993 Sep; 50(3):310-5.GO

Abstract

The prognosis of adenosquamous carcinoma of the cervix compared to the pure cell types of this disease is a controversial issue. Survival rates vary widely among published series, with some authors finding the prognosis to be much worse and others finding it to be equal. We have studied a group of 290 patients, all of whom had the diagnosis of stage IB or IIA cervical cancer, and all of whom were treated by radical hysterectomy and bilateral pelvic and paraaortic lymphadenectomy. The pathology specimens were reviewed for every case. Median follow-up for all living patients was 73 months. Forty-five patients (15.5%) had adenosquamous histology, 220 (75.9%) had squamous cell, and 25 (8.6%) had adenocarcinoma. By X2, there was no significant difference among the three groups with regard to race, economic status, number of grade 3 lesions, number with positive pelvic lymph nodes, number with positive margins, stage distribution (IB vs IIA), or number of recurrences. Using Student's t test, there was no significant difference between any combination of two groups with regard to mean patient age, mean depth of invasion, or mean tumor size. Estimated disease-free survival and overall survival were not different among the three cell types. We conclude that for early stage cervical cancer treated by radical hysterectomy, the adenosquamous cell type does not carry a worse prognosis than either of the pure cell types.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida 33136.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8406193

Citation

Harrison, T A., et al. "Adenosquamous Carcinoma of the Cervix: Prognosis in Early Stage Disease Treated By Radical Hysterectomy." Gynecologic Oncology, vol. 50, no. 3, 1993, pp. 310-5.
Harrison TA, Sevin BU, Koechli O, et al. Adenosquamous carcinoma of the cervix: prognosis in early stage disease treated by radical hysterectomy. Gynecol Oncol. 1993;50(3):310-5.
Harrison, T. A., Sevin, B. U., Koechli, O., Nguyen, H. N., Averette, H. E., Penalver, M., Donato, D. M., & Nadji, M. (1993). Adenosquamous carcinoma of the cervix: prognosis in early stage disease treated by radical hysterectomy. Gynecologic Oncology, 50(3), 310-5.
Harrison TA, et al. Adenosquamous Carcinoma of the Cervix: Prognosis in Early Stage Disease Treated By Radical Hysterectomy. Gynecol Oncol. 1993;50(3):310-5. PubMed PMID: 8406193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adenosquamous carcinoma of the cervix: prognosis in early stage disease treated by radical hysterectomy. AU - Harrison,T A, AU - Sevin,B U, AU - Koechli,O, AU - Nguyen,H N, AU - Averette,H E, AU - Penalver,M, AU - Donato,D M, AU - Nadji,M, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 310 EP - 5 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 50 IS - 3 N2 - The prognosis of adenosquamous carcinoma of the cervix compared to the pure cell types of this disease is a controversial issue. Survival rates vary widely among published series, with some authors finding the prognosis to be much worse and others finding it to be equal. We have studied a group of 290 patients, all of whom had the diagnosis of stage IB or IIA cervical cancer, and all of whom were treated by radical hysterectomy and bilateral pelvic and paraaortic lymphadenectomy. The pathology specimens were reviewed for every case. Median follow-up for all living patients was 73 months. Forty-five patients (15.5%) had adenosquamous histology, 220 (75.9%) had squamous cell, and 25 (8.6%) had adenocarcinoma. By X2, there was no significant difference among the three groups with regard to race, economic status, number of grade 3 lesions, number with positive pelvic lymph nodes, number with positive margins, stage distribution (IB vs IIA), or number of recurrences. Using Student's t test, there was no significant difference between any combination of two groups with regard to mean patient age, mean depth of invasion, or mean tumor size. Estimated disease-free survival and overall survival were not different among the three cell types. We conclude that for early stage cervical cancer treated by radical hysterectomy, the adenosquamous cell type does not carry a worse prognosis than either of the pure cell types. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/8406193/Adenosquamous_carcinoma_of_the_cervix:_prognosis_in_early_stage_disease_treated_by_radical_hysterectomy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(83)71217-5 DB - PRIME DP - Unbound Medicine ER -