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Cholecystokinin does not delay gastric emptying of regular meals in healthy humans.
Hepatogastroenterology. 1993 Aug; 40(4):380-3.H

Abstract

Exogenous CCK can delay gastric emptying of meals in the experimental animal and in humans. Studies using exogenous CCK, however, do not prove that the effects of exogenous peptide are of physiological importance. For this reason, the present study employed the specific CCK-antagonist loxiglumide (Rotta) to investigate the question as to whether CCK plays a physiological role in the regulation of gastric emptying. (1) Sonographic studies: Fourteen healthy subjects received a mixed solid-liquid 1,000 kcal meal made up of regular German food. Gastric emptying was calculated from antral volumes measured at 10-minute intervals. All subjects were studied twice on separate days, either with or without i.v. infusion of 1.0, 5.0 or 10.0 mg/kg h loxiglumide, each different dose being given to 4 or 5 subjects. (2) Scintigraphic studies: Eight subjects received an 800 kcal mixed solid-liquid meal consisting of regular food. Solid and liquid components were labeled with 99m-Tc and 113m-In, respectively. Gastric emptying was monitored using a computerized gamma-camera. All subjects were studied twice on separate days either with or without i.v. infusion of 5 mg/kg h loxiglumide. Both meals significantly increased plasma activity of CCK by 4-8 pM/ml (bioassay). However, loxiglumide did not significantly alter gastric emptying at any postprandial time when compared with the NaCl control. The failure of the CCK-antagonist to affect gastric emptying was seen with both type of meals and both the sonographic and scintigraphic techniques. In the scintigraphic studies, gastric emptying of both liquid and solid components were virtually identical in experiments with or without loxiglumide.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, Heinrich-Heine-University of Düsseldorf, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8406310

Citation

Niederau, C, et al. "Cholecystokinin Does Not Delay Gastric Emptying of Regular Meals in Healthy Humans." Hepato-gastroenterology, vol. 40, no. 4, 1993, pp. 380-3.
Niederau C, Mecklenbeck W, Heindges T. Cholecystokinin does not delay gastric emptying of regular meals in healthy humans. Hepatogastroenterology. 1993;40(4):380-3.
Niederau, C., Mecklenbeck, W., & Heindges, T. (1993). Cholecystokinin does not delay gastric emptying of regular meals in healthy humans. Hepato-gastroenterology, 40(4), 380-3.
Niederau C, Mecklenbeck W, Heindges T. Cholecystokinin Does Not Delay Gastric Emptying of Regular Meals in Healthy Humans. Hepatogastroenterology. 1993;40(4):380-3. PubMed PMID: 8406310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholecystokinin does not delay gastric emptying of regular meals in healthy humans. AU - Niederau,C, AU - Mecklenbeck,W, AU - Heindges,T, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 380 EP - 3 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 40 IS - 4 N2 - Exogenous CCK can delay gastric emptying of meals in the experimental animal and in humans. Studies using exogenous CCK, however, do not prove that the effects of exogenous peptide are of physiological importance. For this reason, the present study employed the specific CCK-antagonist loxiglumide (Rotta) to investigate the question as to whether CCK plays a physiological role in the regulation of gastric emptying. (1) Sonographic studies: Fourteen healthy subjects received a mixed solid-liquid 1,000 kcal meal made up of regular German food. Gastric emptying was calculated from antral volumes measured at 10-minute intervals. All subjects were studied twice on separate days, either with or without i.v. infusion of 1.0, 5.0 or 10.0 mg/kg h loxiglumide, each different dose being given to 4 or 5 subjects. (2) Scintigraphic studies: Eight subjects received an 800 kcal mixed solid-liquid meal consisting of regular food. Solid and liquid components were labeled with 99m-Tc and 113m-In, respectively. Gastric emptying was monitored using a computerized gamma-camera. All subjects were studied twice on separate days either with or without i.v. infusion of 5 mg/kg h loxiglumide. Both meals significantly increased plasma activity of CCK by 4-8 pM/ml (bioassay). However, loxiglumide did not significantly alter gastric emptying at any postprandial time when compared with the NaCl control. The failure of the CCK-antagonist to affect gastric emptying was seen with both type of meals and both the sonographic and scintigraphic techniques. In the scintigraphic studies, gastric emptying of both liquid and solid components were virtually identical in experiments with or without loxiglumide.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/8406310/Cholecystokinin_does_not_delay_gastric_emptying_of_regular_meals_in_healthy_humans_ DB - PRIME DP - Unbound Medicine ER -