Tags

Type your tag names separated by a space and hit enter

Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene.
Int Arch Occup Environ Health. 1993; 65(1 Suppl):S123-6.IA

Abstract

Blood and urine samples were collected from 57 male Japanese solvent workers [exposed to n-hexane (Hex-A), ethyl acetate, and toluene (Tol-A) at 1.5, 2.3, and 2.3 ppm as GM-TWA, respectively] and also from 20 male nonexposed workers at the end of a 8-h shift, and analyzed for n-hexane (Hex-B) and toluene (Tol-B) in blood, and n-hexane (Hex-U), toluene (Tol-U), 2,5-hexanedione [both with (HD-U/cHYD) and without hydrolysis (HD-U/sHYD)] and hippuric acid (HA-U) in urine. Regression analysis showed that both Hex-B and Tol-B correlated significantly with corresponding exposure to the solvents. Solvents in urine (Hex-U and Tol-U) also correlated with solvents in air but with smaller correlation coefficients than the solvents in blood. Both HD-U/cHYD and HD-U/sHYD showed significant correlation with Hex-A, but HA-U failed to do so with Tol-A. Based on the correlation among biological exposure indicators and solvent concentration in air, sensitivity as an exposure indicator was compared between the solvent in blood and the metabolite in urine in terms of the lowest solvent concentration at which the exposed can be separated (with statistical significance) from the nonexposed (the lowest separation concentration; LSC). The LSC was 3.9 ppm for Hex-B, 1 to 2 ppm for HD-U/sHYD and 10 to 30 ppm for HD-U/cHYD, suggesting that HD-U/sHYD is superior even to Hex-B in detecting low n-hexane exposure; this high sensitivity of HD-U/sHYD is due to the absence of HD-U/sHYD in the urine from the nonexposed.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Osaka Occupational Health Center, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8406907

Citation

Kawai, T, et al. "Comparative Evaluation of Blood and Urine Analysis as a Tool for Biological Monitoring of N-hexane and Toluene." International Archives of Occupational and Environmental Health, vol. 65, no. 1 Suppl, 1993, pp. S123-6.
Kawai T, Yasugi T, Mizunuma K, et al. Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene. Int Arch Occup Environ Health. 1993;65(1 Suppl):S123-6.
Kawai, T., Yasugi, T., Mizunuma, K., Horiguchi, S., & Ikeda, M. (1993). Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene. International Archives of Occupational and Environmental Health, 65(1 Suppl), S123-6.
Kawai T, et al. Comparative Evaluation of Blood and Urine Analysis as a Tool for Biological Monitoring of N-hexane and Toluene. Int Arch Occup Environ Health. 1993;65(1 Suppl):S123-6. PubMed PMID: 8406907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene. AU - Kawai,T, AU - Yasugi,T, AU - Mizunuma,K, AU - Horiguchi,S, AU - Ikeda,M, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - S123 EP - 6 JF - International archives of occupational and environmental health JO - Int Arch Occup Environ Health VL - 65 IS - 1 Suppl N2 - Blood and urine samples were collected from 57 male Japanese solvent workers [exposed to n-hexane (Hex-A), ethyl acetate, and toluene (Tol-A) at 1.5, 2.3, and 2.3 ppm as GM-TWA, respectively] and also from 20 male nonexposed workers at the end of a 8-h shift, and analyzed for n-hexane (Hex-B) and toluene (Tol-B) in blood, and n-hexane (Hex-U), toluene (Tol-U), 2,5-hexanedione [both with (HD-U/cHYD) and without hydrolysis (HD-U/sHYD)] and hippuric acid (HA-U) in urine. Regression analysis showed that both Hex-B and Tol-B correlated significantly with corresponding exposure to the solvents. Solvents in urine (Hex-U and Tol-U) also correlated with solvents in air but with smaller correlation coefficients than the solvents in blood. Both HD-U/cHYD and HD-U/sHYD showed significant correlation with Hex-A, but HA-U failed to do so with Tol-A. Based on the correlation among biological exposure indicators and solvent concentration in air, sensitivity as an exposure indicator was compared between the solvent in blood and the metabolite in urine in terms of the lowest solvent concentration at which the exposed can be separated (with statistical significance) from the nonexposed (the lowest separation concentration; LSC). The LSC was 3.9 ppm for Hex-B, 1 to 2 ppm for HD-U/sHYD and 10 to 30 ppm for HD-U/cHYD, suggesting that HD-U/sHYD is superior even to Hex-B in detecting low n-hexane exposure; this high sensitivity of HD-U/sHYD is due to the absence of HD-U/sHYD in the urine from the nonexposed.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0340-0131 UR - https://www.unboundmedicine.com/medline/citation/8406907/Comparative_evaluation_of_blood_and_urine_analysis_as_a_tool_for_biological_monitoring_of_n_hexane_and_toluene_ L2 - https://medlineplus.gov/occupationalhealth.html DB - PRIME DP - Unbound Medicine ER -