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Intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate antimony.
Int J Dermatol. 1993 Aug; 32(8):610-2.IJ

Abstract

BACKGROUND

Cutaneous leishmaniasis represents a difficult disease to manage in endemic areas. Systemic treatment is hampered by both expense and compliance. Side effects may play a major role in this aspect as well.

METHODS

The effectiveness of intralesional treatment of leishmaniasis was investigated. Seven hundred and ten patients were treated with injections of sodium stibogluconate intralesionally. The clinical diagnosis was confirmed by demonstrating the parasite in the smears obtained from the lesion. Fine insulin needle was used to infiltrate the lesion with sodium stibogluconate (0.5 to 1.0 mL).

RESULTS

Generally eight injections were sufficient, but some of the complicated lesions needed up to 24 injections. Sixty-two percent of patients were men. The majority of the study population (64%) were children below 15 years of age. The results showed that 72% of lesions healed completely, 23.9% showed some improvement, while 4.1% showed some deterioration. Lesions of the lips, cheeks, chin, and neck healed faster than lesions in other parts of the body. Side effects were mild and limited to pain at the site of the injection and hyperpigmentation in those who were treated by folk medicine.

CONCLUSIONS

Intralesional treatment is as effective as the standard systemic antimonials. It offers a less expensive alternative and a low side effects profile. Our findings confirmed the findings of earlier workers. It is recommended for treatment of cutaneous leishmaniasis in endemic areas.

Authors+Show Affiliations

Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

8407083

Citation

Faris, R M., et al. "Intralesional Treatment of Cutaneous Leishmaniasis With Sodium Stibogluconate Antimony." International Journal of Dermatology, vol. 32, no. 8, 1993, pp. 610-2.
Faris RM, Jarallah JS, Khoja TA, et al. Intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate antimony. Int J Dermatol. 1993;32(8):610-2.
Faris, R. M., Jarallah, J. S., Khoja, T. A., & al-Yamani, M. J. (1993). Intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate antimony. International Journal of Dermatology, 32(8), 610-2.
Faris RM, et al. Intralesional Treatment of Cutaneous Leishmaniasis With Sodium Stibogluconate Antimony. Int J Dermatol. 1993;32(8):610-2. PubMed PMID: 8407083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate antimony. AU - Faris,R M, AU - Jarallah,J S, AU - Khoja,T A, AU - al-Yamani,M J, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 610 EP - 2 JF - International journal of dermatology JO - Int J Dermatol VL - 32 IS - 8 N2 - BACKGROUND: Cutaneous leishmaniasis represents a difficult disease to manage in endemic areas. Systemic treatment is hampered by both expense and compliance. Side effects may play a major role in this aspect as well. METHODS: The effectiveness of intralesional treatment of leishmaniasis was investigated. Seven hundred and ten patients were treated with injections of sodium stibogluconate intralesionally. The clinical diagnosis was confirmed by demonstrating the parasite in the smears obtained from the lesion. Fine insulin needle was used to infiltrate the lesion with sodium stibogluconate (0.5 to 1.0 mL). RESULTS: Generally eight injections were sufficient, but some of the complicated lesions needed up to 24 injections. Sixty-two percent of patients were men. The majority of the study population (64%) were children below 15 years of age. The results showed that 72% of lesions healed completely, 23.9% showed some improvement, while 4.1% showed some deterioration. Lesions of the lips, cheeks, chin, and neck healed faster than lesions in other parts of the body. Side effects were mild and limited to pain at the site of the injection and hyperpigmentation in those who were treated by folk medicine. CONCLUSIONS: Intralesional treatment is as effective as the standard systemic antimonials. It offers a less expensive alternative and a low side effects profile. Our findings confirmed the findings of earlier workers. It is recommended for treatment of cutaneous leishmaniasis in endemic areas. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/8407083/Intralesional_treatment_of_cutaneous_leishmaniasis_with_sodium_stibogluconate_antimony_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=1993&volume=32&issue=8&spage=610 DB - PRIME DP - Unbound Medicine ER -