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Dietary fat, calories, and the risk of breast cancer in postmenopausal women: a prospective population-based study.

Abstract

We tested the hypothesis that a high-fat diet increases the risk of breast cancer in a population-based study of 590 women aged 40-79 years who were without known breast cancer when they provided a quantitative 24-hour diet recall. Fifteen postmenopausal women were diagnosed with incident breast cancer during the next 15 years (approximately 7600 person-years of follow-up). These women had significantly higher age-adjusted intake of all fats (monounsaturated, polyunsaturated, and saturated), and oleic, linoleic, and linolenic acids, with a stepwise increase in risk across tertiles of intake. Fat intake was associated with total calories, protein, and carbohydrates, and women with incident breast cancer consumed more calories, protein, and carbohydrates than did other subjects. When each nutrient variable (calories, fats, protein, and carbohydrates) was adjusted for age, body mass index, age at menopause, parity, and alcohol consumption, the strongest risks for incident breast cancer were associated with total calories (relative risk per standard deviation = 2.72, 95% confidence interval = 1.51-4.89, p = 0.002) and total fats (relative risk per standard deviation = 2.01, 95% confidence interval = 1.19-3.41, p = 0.01). Fat composition of the diet, expressed either as percent of energy or as fat intake adjusted for calories by regression analysis, was not significantly associated with risk of breast cancer. These results support the hypothesis that total calorie consumption, as well as dietary fat consumption, is a risk factor for breast cancer in postmenopausal women, and parallel observations in animal models.

Authors+Show Affiliations

,

Dept. of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093-0607.

Source

MeSH

Adult
Aged
Alcohol Drinking
Breast Neoplasms
Cohort Studies
Dietary Fats
Energy Intake
Estrogen Replacement Therapy
Fatty Acids
Female
Humans
Incidence
Middle Aged
Multivariate Analysis
Postmenopause
Prospective Studies
Risk Factors
Smoking

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8409101

Citation

Barrett-Connor, E, and N J. Friedlander. "Dietary Fat, Calories, and the Risk of Breast Cancer in Postmenopausal Women: a Prospective Population-based Study." Journal of the American College of Nutrition, vol. 12, no. 4, 1993, pp. 390-9.
Barrett-Connor E, Friedlander NJ. Dietary fat, calories, and the risk of breast cancer in postmenopausal women: a prospective population-based study. J Am Coll Nutr. 1993;12(4):390-9.
Barrett-Connor, E., & Friedlander, N. J. (1993). Dietary fat, calories, and the risk of breast cancer in postmenopausal women: a prospective population-based study. Journal of the American College of Nutrition, 12(4), pp. 390-9.
Barrett-Connor E, Friedlander NJ. Dietary Fat, Calories, and the Risk of Breast Cancer in Postmenopausal Women: a Prospective Population-based Study. J Am Coll Nutr. 1993;12(4):390-9. PubMed PMID: 8409101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat, calories, and the risk of breast cancer in postmenopausal women: a prospective population-based study. AU - Barrett-Connor,E, AU - Friedlander,N J, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 390 EP - 9 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 12 IS - 4 N2 - We tested the hypothesis that a high-fat diet increases the risk of breast cancer in a population-based study of 590 women aged 40-79 years who were without known breast cancer when they provided a quantitative 24-hour diet recall. Fifteen postmenopausal women were diagnosed with incident breast cancer during the next 15 years (approximately 7600 person-years of follow-up). These women had significantly higher age-adjusted intake of all fats (monounsaturated, polyunsaturated, and saturated), and oleic, linoleic, and linolenic acids, with a stepwise increase in risk across tertiles of intake. Fat intake was associated with total calories, protein, and carbohydrates, and women with incident breast cancer consumed more calories, protein, and carbohydrates than did other subjects. When each nutrient variable (calories, fats, protein, and carbohydrates) was adjusted for age, body mass index, age at menopause, parity, and alcohol consumption, the strongest risks for incident breast cancer were associated with total calories (relative risk per standard deviation = 2.72, 95% confidence interval = 1.51-4.89, p = 0.002) and total fats (relative risk per standard deviation = 2.01, 95% confidence interval = 1.19-3.41, p = 0.01). Fat composition of the diet, expressed either as percent of energy or as fat intake adjusted for calories by regression analysis, was not significantly associated with risk of breast cancer. These results support the hypothesis that total calorie consumption, as well as dietary fat consumption, is a risk factor for breast cancer in postmenopausal women, and parallel observations in animal models. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/8409101/Dietary_fat_calories_and_the_risk_of_breast_cancer_in_postmenopausal_women:_a_prospective_population_based_study_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -