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Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.
Metabolism. 1993 Oct; 42(10):1270-6.M

Abstract

Abnormalities of thyroid hormone levels have been reported in the acquired immunodeficiency syndrome (AIDS), but there has been debate as to whether they are appropriate for the clinical status of the patients. Inappropriate maintenance of circulating 3,3',5-triiodothyronine (T3) levels could contribute to weight loss. Although many patients with AIDS have a history of wasting, recent data indicate that prolonged periods of stable weight occur in AIDS and that short-term weight loss is present in a subset of patients with anorexia, many of whom have active secondary infection (AIDS-SI). Therefore we analyzed thyroid hormone levels in a cohort of subjects that have been characterized in terms of recent weight loss and caloric intake. Asymptomatic patients with human immunodeficiency virus infection (HIV+) had short-term stable weights, normal caloric intake, and normal serum T3 levels. In AIDS, average short-term weight was stable, caloric intake was normal, and T3 levels were decreased by 19%. In AIDS-SI, both short-term weight loss and anorexia were significant, and this group showed a 45% decrease in T3 levels. The free T3 (FT3) index was decreased by 30% in AIDS and by 50% in AIDS-SI. Free thyroxine (FT4) levels were decreased while thyroxine-binding globulin (TBG) capacity was increased in HIV+ and AIDS; TBG sialylation was unchanged. Thyrotropin (TSH) levels were slightly increased in AIDS, although levels remained within the normal range. 3,3',5'-triiodothyronine (rT3) levels were decreased in HIV+, AIDS, and AIDS-SI. Thus asymptomatic patients with HIV infection whose weight is stable maintain normal T3 levels.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, University of California, San Francisco.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8412739

Citation

Grunfeld, C, et al. "Indices of Thyroid Function and Weight Loss in Human Immunodeficiency Virus Infection and the Acquired Immunodeficiency Syndrome." Metabolism: Clinical and Experimental, vol. 42, no. 10, 1993, pp. 1270-6.
Grunfeld C, Pang M, Doerrler W, et al. Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. Metab Clin Exp. 1993;42(10):1270-6.
Grunfeld, C., Pang, M., Doerrler, W., Jensen, P., Shimizu, L., Feingold, K. R., & Cavalieri, R. R. (1993). Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. Metabolism: Clinical and Experimental, 42(10), 1270-6.
Grunfeld C, et al. Indices of Thyroid Function and Weight Loss in Human Immunodeficiency Virus Infection and the Acquired Immunodeficiency Syndrome. Metab Clin Exp. 1993;42(10):1270-6. PubMed PMID: 8412739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. AU - Grunfeld,C, AU - Pang,M, AU - Doerrler,W, AU - Jensen,P, AU - Shimizu,L, AU - Feingold,K R, AU - Cavalieri,R R, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 1270 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 42 IS - 10 N2 - Abnormalities of thyroid hormone levels have been reported in the acquired immunodeficiency syndrome (AIDS), but there has been debate as to whether they are appropriate for the clinical status of the patients. Inappropriate maintenance of circulating 3,3',5-triiodothyronine (T3) levels could contribute to weight loss. Although many patients with AIDS have a history of wasting, recent data indicate that prolonged periods of stable weight occur in AIDS and that short-term weight loss is present in a subset of patients with anorexia, many of whom have active secondary infection (AIDS-SI). Therefore we analyzed thyroid hormone levels in a cohort of subjects that have been characterized in terms of recent weight loss and caloric intake. Asymptomatic patients with human immunodeficiency virus infection (HIV+) had short-term stable weights, normal caloric intake, and normal serum T3 levels. In AIDS, average short-term weight was stable, caloric intake was normal, and T3 levels were decreased by 19%. In AIDS-SI, both short-term weight loss and anorexia were significant, and this group showed a 45% decrease in T3 levels. The free T3 (FT3) index was decreased by 30% in AIDS and by 50% in AIDS-SI. Free thyroxine (FT4) levels were decreased while thyroxine-binding globulin (TBG) capacity was increased in HIV+ and AIDS; TBG sialylation was unchanged. Thyrotropin (TSH) levels were slightly increased in AIDS, although levels remained within the normal range. 3,3',5'-triiodothyronine (rT3) levels were decreased in HIV+, AIDS, and AIDS-SI. Thus asymptomatic patients with HIV infection whose weight is stable maintain normal T3 levels.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/8412739/Indices_of_thyroid_function_and_weight_loss_in_human_immunodeficiency_virus_infection_and_the_acquired_immunodeficiency_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(93)90124-7 DB - PRIME DP - Unbound Medicine ER -