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A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep-vein thrombosis in symptomatic outpatients.
N Engl J Med. 1993 Nov 04; 329(19):1365-9.NEJM

Abstract

BACKGROUND

Impedance plethysmography performed serially over a one-week period has been shown to be an effective diagnostic strategy for patients with clinically suspected acute deep-vein thrombosis. Compression ultrasonography has a high sensitivity and specificity for the detection of proximal-vein thrombosis. The clinical value of repeated ultrasonography in the management of symptomatic deep-vein thrombosis is unknown.

METHODS

We conducted a randomized trial in 985 consecutive outpatients with clinically suspected deep-vein thrombosis to compare the diagnostic value of serial impedance plethysmography (494 patients) and serial compression ultrasonography (491 patients). We compared the positive predictive values of both tests for the diagnosis of venous thrombosis, using contrast venography as a reference. The frequencies of venous thromboembolism during a six-month follow-up period were also compared in patients with repeatedly normal results in order to evaluate the safety of withholding anticoagulant therapy from such patients.

RESULTS

The positive predictive value of an abnormal ultrasonogram was 94 percent (95 percent confidence interval, 87 to 98 percent), whereas the predictive value of impedance plethysmography was 83 percent (95 percent confidence interval, 75 to 90 percent) (P = 0.02). In patients with repeatedly normal results, the incidence of venous thromboembolism during the six-month follow-up period was 1.5 percent (95 percent confidence interval, 0.5 to 3.3 percent) for serial compression ultrasonography, as compared with 2.5 percent (95 percent confidence interval, 1.2 to 4.6 percent) for serial impedance plethysmography.

CONCLUSIONS

In making the diagnosis of deep-vein thrombosis in symptomatic outpatients, serial compression ultrasonography is preferable to impedance plethysmography, in view of its superior performance in detecting venous thrombosis.

Authors+Show Affiliations

Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8413431

Citation

Heijboer, H, et al. "A Comparison of Real-time Compression Ultrasonography With Impedance Plethysmography for the Diagnosis of Deep-vein Thrombosis in Symptomatic Outpatients." The New England Journal of Medicine, vol. 329, no. 19, 1993, pp. 1365-9.
Heijboer H, Büller HR, Lensing AW, et al. A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep-vein thrombosis in symptomatic outpatients. N Engl J Med. 1993;329(19):1365-9.
Heijboer, H., Büller, H. R., Lensing, A. W., Turpie, A. G., Colly, L. P., & ten Cate, J. W. (1993). A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep-vein thrombosis in symptomatic outpatients. The New England Journal of Medicine, 329(19), 1365-9.
Heijboer H, et al. A Comparison of Real-time Compression Ultrasonography With Impedance Plethysmography for the Diagnosis of Deep-vein Thrombosis in Symptomatic Outpatients. N Engl J Med. 1993 Nov 4;329(19):1365-9. PubMed PMID: 8413431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep-vein thrombosis in symptomatic outpatients. AU - Heijboer,H, AU - Büller,H R, AU - Lensing,A W, AU - Turpie,A G, AU - Colly,L P, AU - ten Cate,J W, PY - 1993/11/4/pubmed PY - 1993/11/4/medline PY - 1993/11/4/entrez SP - 1365 EP - 9 JF - The New England journal of medicine JO - N Engl J Med VL - 329 IS - 19 N2 - BACKGROUND: Impedance plethysmography performed serially over a one-week period has been shown to be an effective diagnostic strategy for patients with clinically suspected acute deep-vein thrombosis. Compression ultrasonography has a high sensitivity and specificity for the detection of proximal-vein thrombosis. The clinical value of repeated ultrasonography in the management of symptomatic deep-vein thrombosis is unknown. METHODS: We conducted a randomized trial in 985 consecutive outpatients with clinically suspected deep-vein thrombosis to compare the diagnostic value of serial impedance plethysmography (494 patients) and serial compression ultrasonography (491 patients). We compared the positive predictive values of both tests for the diagnosis of venous thrombosis, using contrast venography as a reference. The frequencies of venous thromboembolism during a six-month follow-up period were also compared in patients with repeatedly normal results in order to evaluate the safety of withholding anticoagulant therapy from such patients. RESULTS: The positive predictive value of an abnormal ultrasonogram was 94 percent (95 percent confidence interval, 87 to 98 percent), whereas the predictive value of impedance plethysmography was 83 percent (95 percent confidence interval, 75 to 90 percent) (P = 0.02). In patients with repeatedly normal results, the incidence of venous thromboembolism during the six-month follow-up period was 1.5 percent (95 percent confidence interval, 0.5 to 3.3 percent) for serial compression ultrasonography, as compared with 2.5 percent (95 percent confidence interval, 1.2 to 4.6 percent) for serial impedance plethysmography. CONCLUSIONS: In making the diagnosis of deep-vein thrombosis in symptomatic outpatients, serial compression ultrasonography is preferable to impedance plethysmography, in view of its superior performance in detecting venous thrombosis. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/8413431/A_comparison_of_real_time_compression_ultrasonography_with_impedance_plethysmography_for_the_diagnosis_of_deep_vein_thrombosis_in_symptomatic_outpatients_ L2 - https://www.nejm.org/doi/10.1056/NEJM199311043291901?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -