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The artificial endocrine pancreas in clinical practice and research. The present position and future perspectives.
Panminerva Med. 1993 Jun; 35(2):67-74.PM

Abstract

The artificial endocrine pancreas (AEP) is a controlled glucose and/or insulin infusion system in which continuously monitored blood sugar values are fed to a computerised analyser that uses predetermined algorithms to establish the doses to be administered. Since its first appearance in clinical practice and diabetological research during the Sixties, the AEP has been modified in various ways to overcome technical problems associated with the gluco-sensor and algorithms so as to make better use of the glucose-insulin feedback mechanism, and hence obtain a closer correspondence to physiological islet cell activity. As a result of these changes, the AEP can be employed in accordance with the physiopathological principles of insulin secretion in a variety of clinical conditions to secure the short-term control of metabolic alterations in the diabetic. Surgery is one field in which the AEP is used to great advantage, since this and its accompanying anaesthetics are the source of stress, which in turn may result in a rapid and sometimes serious postoperative metabolic derangement, including an increased secretion of anti-insulin hormones. The AEP has also been proposed for diabetic pregnancy and for the treatment of subjects in diabetic coma. It has proved useful in the diagnosis and management of hypoglycaemia due to organic hyperinsulinism, in diabetics with renal failure, in the honeymoon period, and in cases of unstable diabetes. The versatility of its application and its underlying physiopathological principles have enabled the AEP to be predominantly employed in research.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Institute of Internal Medicine, University of Turin, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8414626

Citation

Marena, S, et al. "The Artificial Endocrine Pancreas in Clinical Practice and Research. the Present Position and Future Perspectives." Panminerva Medica, vol. 35, no. 2, 1993, pp. 67-74.
Marena S, Imperiale G, Pagano G. The artificial endocrine pancreas in clinical practice and research. The present position and future perspectives. Panminerva Med. 1993;35(2):67-74.
Marena, S., Imperiale, G., & Pagano, G. (1993). The artificial endocrine pancreas in clinical practice and research. The present position and future perspectives. Panminerva Medica, 35(2), 67-74.
Marena S, Imperiale G, Pagano G. The Artificial Endocrine Pancreas in Clinical Practice and Research. the Present Position and Future Perspectives. Panminerva Med. 1993;35(2):67-74. PubMed PMID: 8414626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The artificial endocrine pancreas in clinical practice and research. The present position and future perspectives. AU - Marena,S, AU - Imperiale,G, AU - Pagano,G, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 67 EP - 74 JF - Panminerva medica JO - Panminerva Med VL - 35 IS - 2 N2 - The artificial endocrine pancreas (AEP) is a controlled glucose and/or insulin infusion system in which continuously monitored blood sugar values are fed to a computerised analyser that uses predetermined algorithms to establish the doses to be administered. Since its first appearance in clinical practice and diabetological research during the Sixties, the AEP has been modified in various ways to overcome technical problems associated with the gluco-sensor and algorithms so as to make better use of the glucose-insulin feedback mechanism, and hence obtain a closer correspondence to physiological islet cell activity. As a result of these changes, the AEP can be employed in accordance with the physiopathological principles of insulin secretion in a variety of clinical conditions to secure the short-term control of metabolic alterations in the diabetic. Surgery is one field in which the AEP is used to great advantage, since this and its accompanying anaesthetics are the source of stress, which in turn may result in a rapid and sometimes serious postoperative metabolic derangement, including an increased secretion of anti-insulin hormones. The AEP has also been proposed for diabetic pregnancy and for the treatment of subjects in diabetic coma. It has proved useful in the diagnosis and management of hypoglycaemia due to organic hyperinsulinism, in diabetics with renal failure, in the honeymoon period, and in cases of unstable diabetes. The versatility of its application and its underlying physiopathological principles have enabled the AEP to be predominantly employed in research.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0031-0808 UR - https://www.unboundmedicine.com/medline/citation/8414626/The_artificial_endocrine_pancreas_in_clinical_practice_and_research__The_present_position_and_future_perspectives_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:8414626 DB - PRIME DP - Unbound Medicine ER -
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