Tags

Type your tag names separated by a space and hit enter

A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer.
Cancer Res 1993; 53(1):75-82CR

Abstract

In 1986 a prospective cohort study on diet and cancer was started in the Netherlands among 62,573 women ages 55-69 years. Baseline information on diet and other risk factors was collected with a questionnaire. Cancer incidence was measured by record linkage with cancer registries and a pathology register. A case-cohort approach was used, in which the accumulated person time in the cohort was estimated by follow-up of a randomly selected subcohort (n = 1812). After 3.3 years of follow-up, 471 incident breast cancer cases were available for analysis. Questionnaire data for these cases and the 1716 female subcohort members without a history of cancer other than skin cancer were analyzed. In a multivariate analysis, controlling for traditional risk factors, the relative rates for breast cancer in increasing quintiles of energy-adjusted total fat intake were 1.00, 1.00, 1.34, 1.22, 1.08 (P-trend, 0.32). For saturated fat there was some evidence for a weak positive association when quintiles were used (relative rates in quintiles 1-5, 1.00, 1.22, 1.22, 1.38, 1.39; P-trend, 0.049). The 95% confidence interval (CI) for the top quintile was 0.94-2.06, however; and when saturated fat was used as a continuous variable, the effect was no longer significant (P = 0.20). Relative rate estimates for the highest versus lowest quintiles of monounsaturated fat, polyunsaturated fat, and cholesterol intake were 0.75 (95% CI, 0.50-1.12), 0.95 (95% CI, 0.64-1.40) and 1.09 (95% CI, 0.74-1.61), respectively, with no evidence for significant trends. This prospective study does not support a major role of dietary fat in the etiology of postmenopausal breast cancer.

Authors+Show Affiliations

Department of Epidemiology, University of Limburg, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8416752

Citation

van den Brandt, P A., et al. "A Prospective Cohort Study On Dietary Fat and the Risk of Postmenopausal Breast Cancer." Cancer Research, vol. 53, no. 1, 1993, pp. 75-82.
van den Brandt PA, van't Veer P, Goldbohm RA, et al. A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. Cancer Res. 1993;53(1):75-82.
van den Brandt, P. A., van't Veer, P., Goldbohm, R. A., Dorant, E., Volovics, A., Hermus, R. J., & Sturmans, F. (1993). A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. Cancer Research, 53(1), pp. 75-82.
van den Brandt PA, et al. A Prospective Cohort Study On Dietary Fat and the Risk of Postmenopausal Breast Cancer. Cancer Res. 1993 Jan 1;53(1):75-82. PubMed PMID: 8416752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. AU - van den Brandt,P A, AU - van't Veer,P, AU - Goldbohm,R A, AU - Dorant,E, AU - Volovics,A, AU - Hermus,R J, AU - Sturmans,F, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 75 EP - 82 JF - Cancer research JO - Cancer Res. VL - 53 IS - 1 N2 - In 1986 a prospective cohort study on diet and cancer was started in the Netherlands among 62,573 women ages 55-69 years. Baseline information on diet and other risk factors was collected with a questionnaire. Cancer incidence was measured by record linkage with cancer registries and a pathology register. A case-cohort approach was used, in which the accumulated person time in the cohort was estimated by follow-up of a randomly selected subcohort (n = 1812). After 3.3 years of follow-up, 471 incident breast cancer cases were available for analysis. Questionnaire data for these cases and the 1716 female subcohort members without a history of cancer other than skin cancer were analyzed. In a multivariate analysis, controlling for traditional risk factors, the relative rates for breast cancer in increasing quintiles of energy-adjusted total fat intake were 1.00, 1.00, 1.34, 1.22, 1.08 (P-trend, 0.32). For saturated fat there was some evidence for a weak positive association when quintiles were used (relative rates in quintiles 1-5, 1.00, 1.22, 1.22, 1.38, 1.39; P-trend, 0.049). The 95% confidence interval (CI) for the top quintile was 0.94-2.06, however; and when saturated fat was used as a continuous variable, the effect was no longer significant (P = 0.20). Relative rate estimates for the highest versus lowest quintiles of monounsaturated fat, polyunsaturated fat, and cholesterol intake were 0.75 (95% CI, 0.50-1.12), 0.95 (95% CI, 0.64-1.40) and 1.09 (95% CI, 0.74-1.61), respectively, with no evidence for significant trends. This prospective study does not support a major role of dietary fat in the etiology of postmenopausal breast cancer. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/8416752/A_prospective_cohort_study_on_dietary_fat_and_the_risk_of_postmenopausal_breast_cancer_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8416752 DB - PRIME DP - Unbound Medicine ER -