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A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer.

Abstract

In 1986 a prospective cohort study on diet and cancer was started in the Netherlands among 62,573 women ages 55-69 years. Baseline information on diet and other risk factors was collected with a questionnaire. Cancer incidence was measured by record linkage with cancer registries and a pathology register. A case-cohort approach was used, in which the accumulated person time in the cohort was estimated by follow-up of a randomly selected subcohort (n = 1812). After 3.3 years of follow-up, 471 incident breast cancer cases were available for analysis. Questionnaire data for these cases and the 1716 female subcohort members without a history of cancer other than skin cancer were analyzed. In a multivariate analysis, controlling for traditional risk factors, the relative rates for breast cancer in increasing quintiles of energy-adjusted total fat intake were 1.00, 1.00, 1.34, 1.22, 1.08 (P-trend, 0.32). For saturated fat there was some evidence for a weak positive association when quintiles were used (relative rates in quintiles 1-5, 1.00, 1.22, 1.22, 1.38, 1.39; P-trend, 0.049). The 95% confidence interval (CI) for the top quintile was 0.94-2.06, however; and when saturated fat was used as a continuous variable, the effect was no longer significant (P = 0.20). Relative rate estimates for the highest versus lowest quintiles of monounsaturated fat, polyunsaturated fat, and cholesterol intake were 0.75 (95% CI, 0.50-1.12), 0.95 (95% CI, 0.64-1.40) and 1.09 (95% CI, 0.74-1.61), respectively, with no evidence for significant trends. This prospective study does not support a major role of dietary fat in the etiology of postmenopausal breast cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of Limburg, Maastricht, The Netherlands.

    , , , , ,

    Source

    Cancer research 53:1 1993 Jan 01 pg 75-82

    MeSH

    Aged
    Breast Neoplasms
    Cohort Studies
    Dietary Fats
    Female
    Humans
    Incidence
    Menopause
    Middle Aged
    Netherlands
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8416752

    Citation

    van den Brandt, P A., et al. "A Prospective Cohort Study On Dietary Fat and the Risk of Postmenopausal Breast Cancer." Cancer Research, vol. 53, no. 1, 1993, pp. 75-82.
    van den Brandt PA, van't Veer P, Goldbohm RA, et al. A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. Cancer Res. 1993;53(1):75-82.
    van den Brandt, P. A., van't Veer, P., Goldbohm, R. A., Dorant, E., Volovics, A., Hermus, R. J., & Sturmans, F. (1993). A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. Cancer Research, 53(1), pp. 75-82.
    van den Brandt PA, et al. A Prospective Cohort Study On Dietary Fat and the Risk of Postmenopausal Breast Cancer. Cancer Res. 1993 Jan 1;53(1):75-82. PubMed PMID: 8416752.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. AU - van den Brandt,P A, AU - van't Veer,P, AU - Goldbohm,R A, AU - Dorant,E, AU - Volovics,A, AU - Hermus,R J, AU - Sturmans,F, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 75 EP - 82 JF - Cancer research JO - Cancer Res. VL - 53 IS - 1 N2 - In 1986 a prospective cohort study on diet and cancer was started in the Netherlands among 62,573 women ages 55-69 years. Baseline information on diet and other risk factors was collected with a questionnaire. Cancer incidence was measured by record linkage with cancer registries and a pathology register. A case-cohort approach was used, in which the accumulated person time in the cohort was estimated by follow-up of a randomly selected subcohort (n = 1812). After 3.3 years of follow-up, 471 incident breast cancer cases were available for analysis. Questionnaire data for these cases and the 1716 female subcohort members without a history of cancer other than skin cancer were analyzed. In a multivariate analysis, controlling for traditional risk factors, the relative rates for breast cancer in increasing quintiles of energy-adjusted total fat intake were 1.00, 1.00, 1.34, 1.22, 1.08 (P-trend, 0.32). For saturated fat there was some evidence for a weak positive association when quintiles were used (relative rates in quintiles 1-5, 1.00, 1.22, 1.22, 1.38, 1.39; P-trend, 0.049). The 95% confidence interval (CI) for the top quintile was 0.94-2.06, however; and when saturated fat was used as a continuous variable, the effect was no longer significant (P = 0.20). Relative rate estimates for the highest versus lowest quintiles of monounsaturated fat, polyunsaturated fat, and cholesterol intake were 0.75 (95% CI, 0.50-1.12), 0.95 (95% CI, 0.64-1.40) and 1.09 (95% CI, 0.74-1.61), respectively, with no evidence for significant trends. This prospective study does not support a major role of dietary fat in the etiology of postmenopausal breast cancer. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/8416752/A_prospective_cohort_study_on_dietary_fat_and_the_risk_of_postmenopausal_breast_cancer_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8416752 DB - PRIME DP - Unbound Medicine ER -