Abstract
OBJECTIVE
The purpose of this study was to examine key variables in the regulation of coagulation and fibrinolysis during intake of low-dose oral contraceptives containing newly developed progestogens.
STUDY DESIGN
Thirty-four healthy young women were allocated to 12 consecutive cycles of treatment with monophasic combinations of 20 micrograms ethinyl estradiol and 150 micrograms desogestrel (n = 15) or 30 micrograms ethinyl estradiol and 75 micrograms gestodene (n = 19). Nonparametric analysis of variance was used for statistical evaluation.
RESULTS
In both groups plasma levels of fibrinogen and Factor VIIc increased, and the capacity of coagulation inhibition was affected by increased protein C and decreased protein S levels. Increased fibrinolytic capacity was indicated by elevated activity and reduced antigen levels of tissue plasminogen activator and by reduced activity and concentration of plasminogen activator inhibitor. Thrombin-antithrombin III complexes and fibrin degradation products were unchanged, signifying no effect of hormonal intake on the degree of activation of the coagulation system or the efficacy of fibrinolysis.
CONCLUSION
The overall dynamic balance between generation and resolution of fibrin was maintained during treatment with both hormonal compounds. Our findings suggest that the risk of thrombosis in normal women should not be increased.
Pub Type(s)
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
TY - JOUR
T1 - Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women.
AU - Petersen,K R,
AU - Sidelmann,J,
AU - Skouby,S O,
AU - Jespersen,J,
PY - 1993/1/1/pubmed
PY - 1993/1/1/medline
PY - 1993/1/1/entrez
KW - Biology
KW - Blood Coagulation Effects
KW - Contraception
KW - Contraceptive Methods
KW - Denmark
KW - Developed Countries
KW - Europe
KW - Family Planning
KW - Fibrinolysis
KW - Hematological Effects
KW - Hemic System
KW - Northern Europe
KW - Oral Contraceptives
KW - Oral Contraceptives, Low-dose
KW - Physiology
KW - Research Report
KW - Scandinavia
SP - 32
EP - 8
JF - American journal of obstetrics and gynecology
JO - Am J Obstet Gynecol
VL - 168
IS - 1 Pt 1
N2 - OBJECTIVE: The purpose of this study was to examine key variables in the regulation of coagulation and fibrinolysis during intake of low-dose oral contraceptives containing newly developed progestogens. STUDY DESIGN: Thirty-four healthy young women were allocated to 12 consecutive cycles of treatment with monophasic combinations of 20 micrograms ethinyl estradiol and 150 micrograms desogestrel (n = 15) or 30 micrograms ethinyl estradiol and 75 micrograms gestodene (n = 19). Nonparametric analysis of variance was used for statistical evaluation. RESULTS: In both groups plasma levels of fibrinogen and Factor VIIc increased, and the capacity of coagulation inhibition was affected by increased protein C and decreased protein S levels. Increased fibrinolytic capacity was indicated by elevated activity and reduced antigen levels of tissue plasminogen activator and by reduced activity and concentration of plasminogen activator inhibitor. Thrombin-antithrombin III complexes and fibrin degradation products were unchanged, signifying no effect of hormonal intake on the degree of activation of the coagulation system or the efficacy of fibrinolysis. CONCLUSION: The overall dynamic balance between generation and resolution of fibrin was maintained during treatment with both hormonal compounds. Our findings suggest that the risk of thrombosis in normal women should not be increased.
SN - 0002-9378
UR - https://www.unboundmedicine.com/medline/citation/8420344/Effects_of_monophasic_low_dose_oral_contraceptives_on_fibrin_formation_and_resolution_in_young_women_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(12)90880-7
DB - PRIME
DP - Unbound Medicine
ER -
