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Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women.
Am J Obstet Gynecol. 1993 Jan; 168(1 Pt 1):32-8.AJ

Abstract

OBJECTIVE

The purpose of this study was to examine key variables in the regulation of coagulation and fibrinolysis during intake of low-dose oral contraceptives containing newly developed progestogens.

STUDY DESIGN

Thirty-four healthy young women were allocated to 12 consecutive cycles of treatment with monophasic combinations of 20 micrograms ethinyl estradiol and 150 micrograms desogestrel (n = 15) or 30 micrograms ethinyl estradiol and 75 micrograms gestodene (n = 19). Nonparametric analysis of variance was used for statistical evaluation.

RESULTS

In both groups plasma levels of fibrinogen and Factor VIIc increased, and the capacity of coagulation inhibition was affected by increased protein C and decreased protein S levels. Increased fibrinolytic capacity was indicated by elevated activity and reduced antigen levels of tissue plasminogen activator and by reduced activity and concentration of plasminogen activator inhibitor. Thrombin-antithrombin III complexes and fibrin degradation products were unchanged, signifying no effect of hormonal intake on the degree of activation of the coagulation system or the efficacy of fibrinolysis.

CONCLUSION

The overall dynamic balance between generation and resolution of fibrin was maintained during treatment with both hormonal compounds. Our findings suggest that the risk of thrombosis in normal women should not be increased.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8420344

Citation

Petersen, K R., et al. "Effects of Monophasic Low-dose Oral Contraceptives On Fibrin Formation and Resolution in Young Women." American Journal of Obstetrics and Gynecology, vol. 168, no. 1 Pt 1, 1993, pp. 32-8.
Petersen KR, Sidelmann J, Skouby SO, et al. Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women. Am J Obstet Gynecol. 1993;168(1 Pt 1):32-8.
Petersen, K. R., Sidelmann, J., Skouby, S. O., & Jespersen, J. (1993). Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women. American Journal of Obstetrics and Gynecology, 168(1 Pt 1), 32-8.
Petersen KR, et al. Effects of Monophasic Low-dose Oral Contraceptives On Fibrin Formation and Resolution in Young Women. Am J Obstet Gynecol. 1993;168(1 Pt 1):32-8. PubMed PMID: 8420344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women. AU - Petersen,K R, AU - Sidelmann,J, AU - Skouby,S O, AU - Jespersen,J, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez KW - Biology KW - Blood Coagulation Effects KW - Contraception KW - Contraceptive Methods KW - Denmark KW - Developed Countries KW - Europe KW - Family Planning KW - Fibrinolysis KW - Hematological Effects KW - Hemic System KW - Northern Europe KW - Oral Contraceptives KW - Oral Contraceptives, Low-dose KW - Physiology KW - Research Report KW - Scandinavia SP - 32 EP - 8 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 168 IS - 1 Pt 1 N2 - OBJECTIVE: The purpose of this study was to examine key variables in the regulation of coagulation and fibrinolysis during intake of low-dose oral contraceptives containing newly developed progestogens. STUDY DESIGN: Thirty-four healthy young women were allocated to 12 consecutive cycles of treatment with monophasic combinations of 20 micrograms ethinyl estradiol and 150 micrograms desogestrel (n = 15) or 30 micrograms ethinyl estradiol and 75 micrograms gestodene (n = 19). Nonparametric analysis of variance was used for statistical evaluation. RESULTS: In both groups plasma levels of fibrinogen and Factor VIIc increased, and the capacity of coagulation inhibition was affected by increased protein C and decreased protein S levels. Increased fibrinolytic capacity was indicated by elevated activity and reduced antigen levels of tissue plasminogen activator and by reduced activity and concentration of plasminogen activator inhibitor. Thrombin-antithrombin III complexes and fibrin degradation products were unchanged, signifying no effect of hormonal intake on the degree of activation of the coagulation system or the efficacy of fibrinolysis. CONCLUSION: The overall dynamic balance between generation and resolution of fibrin was maintained during treatment with both hormonal compounds. Our findings suggest that the risk of thrombosis in normal women should not be increased. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/8420344/Effects_of_monophasic_low_dose_oral_contraceptives_on_fibrin_formation_and_resolution_in_young_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(12)90880-7 DB - PRIME DP - Unbound Medicine ER -