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Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps.
Cancer Epidemiol Biomarkers Prev 1993 Jan-Feb; 2(1):41-6CE

Abstract

The objective of this cross-sectional study was to determine whether plasma selenium concentration predicts the prevalence of adenomatous polyps of the colon and rectum. The source population for the study was 101 patients undergoing sequential colonoscopies at the Veterans Affairs Medical Center, Tucson, AZ. The study population was then limited to the 48 patients (all male) undergoing their initial colonoscopy who did not have a diagnosis of colorectal cancer. For each of these patients, a prediagnostic fasting plasma selenium concentration was determined. The data from this study suggest that fasting plasma selenium concentrations may be an important risk factor for colorectal adenomas. Patients with fasting plasma selenium concentrations below the median (< 128 mcg/liter) were significantly more likely to have one or more adenomatous polyps (prevalence odds ratio 4.2) and more adenomatous polyps (3.5 times) per patient. There was also a suggestion of a more proximal distribution of adenomatous polyps in the patients with a lower level of selenium. These associations were not confounded by age or smoking. The results of this study are consistent with the experimental animal studies, geographic mortality studies, and prospective cohort studies of selenium and colorectal cancer.

Authors+Show Affiliations

Department of Family and Community Medicine, University of Arizona College of Medicine, Tucson 85716.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8420611

Citation

Clark, L C., et al. "Plasma Selenium Concentration Predicts the Prevalence of Colorectal Adenomatous Polyps." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 2, no. 1, 1993, pp. 41-6.
Clark LC, Hixson LJ, Combs GF, et al. Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev. 1993;2(1):41-6.
Clark, L. C., Hixson, L. J., Combs, G. F., Reid, M. E., Turnbull, B. W., & Sampliner, R. E. (1993). Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 2(1), pp. 41-6.
Clark LC, et al. Plasma Selenium Concentration Predicts the Prevalence of Colorectal Adenomatous Polyps. Cancer Epidemiol Biomarkers Prev. 1993;2(1):41-6. PubMed PMID: 8420611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. AU - Clark,L C, AU - Hixson,L J, AU - Combs,G F,Jr AU - Reid,M E, AU - Turnbull,B W, AU - Sampliner,R E, PY - 1993/1/1/pubmed PY - 2001/3/28/medline PY - 1993/1/1/entrez SP - 41 EP - 6 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 2 IS - 1 N2 - The objective of this cross-sectional study was to determine whether plasma selenium concentration predicts the prevalence of adenomatous polyps of the colon and rectum. The source population for the study was 101 patients undergoing sequential colonoscopies at the Veterans Affairs Medical Center, Tucson, AZ. The study population was then limited to the 48 patients (all male) undergoing their initial colonoscopy who did not have a diagnosis of colorectal cancer. For each of these patients, a prediagnostic fasting plasma selenium concentration was determined. The data from this study suggest that fasting plasma selenium concentrations may be an important risk factor for colorectal adenomas. Patients with fasting plasma selenium concentrations below the median (< 128 mcg/liter) were significantly more likely to have one or more adenomatous polyps (prevalence odds ratio 4.2) and more adenomatous polyps (3.5 times) per patient. There was also a suggestion of a more proximal distribution of adenomatous polyps in the patients with a lower level of selenium. These associations were not confounded by age or smoking. The results of this study are consistent with the experimental animal studies, geographic mortality studies, and prospective cohort studies of selenium and colorectal cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/8420611/Plasma_selenium_concentration_predicts_the_prevalence_of_colorectal_adenomatous_polyps_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=8420611 DB - PRIME DP - Unbound Medicine ER -