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Low-proof alcoholic beverages and gastroesophageal reflux.
Dig Dis Sci 1993; 38(1):93-6DD

Abstract

Previous studies have demonstrated an increased gastroesophageal reflux after the ingestion of high-proof alcoholic beverages in normal subjects. Data on gastroesophageal reflux with usual amounts of low-proof alcoholic beverages are not available. The effect of white wine (7.5% v/v, pH 3.2) and beer (7.0% v/v, pH 4.5) was compared with water, a nonalcoholic beverage of pH 3.2, and an ethanol solution (7.5% v/v, pH 7.6) using ambulatory pH measurement in healthy volunteers. The fraction of time at pH < 4 in the first hour after ingestion of 300 ml white wine (median 13.2%) was significantly increased compared with beer (3.6%; P < 0.01), water (0.9%; P < 0.001), ethanol (1.3%; P < 0.001), and the nonalcoholic beverage (0.9%; P < 0.05). Beer provoked significantly more gastroesophageal reflux than water (P < 0.01). It is concluded that white wine and beer induce gastroesophageal reflux, which is neither related to their ethanol content nor to their pH. The mechanism for this effect remains to be identified.

Authors+Show Affiliations

Department of Medicine, München-Bogenhausen Hospital, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8420765

Citation

Pehl, C, et al. "Low-proof Alcoholic Beverages and Gastroesophageal Reflux." Digestive Diseases and Sciences, vol. 38, no. 1, 1993, pp. 93-6.
Pehl C, Wendl B, Pfeiffer A, et al. Low-proof alcoholic beverages and gastroesophageal reflux. Dig Dis Sci. 1993;38(1):93-6.
Pehl, C., Wendl, B., Pfeiffer, A., Schmidt, T., & Kaess, H. (1993). Low-proof alcoholic beverages and gastroesophageal reflux. Digestive Diseases and Sciences, 38(1), pp. 93-6.
Pehl C, et al. Low-proof Alcoholic Beverages and Gastroesophageal Reflux. Dig Dis Sci. 1993;38(1):93-6. PubMed PMID: 8420765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-proof alcoholic beverages and gastroesophageal reflux. AU - Pehl,C, AU - Wendl,B, AU - Pfeiffer,A, AU - Schmidt,T, AU - Kaess,H, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 93 EP - 6 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 38 IS - 1 N2 - Previous studies have demonstrated an increased gastroesophageal reflux after the ingestion of high-proof alcoholic beverages in normal subjects. Data on gastroesophageal reflux with usual amounts of low-proof alcoholic beverages are not available. The effect of white wine (7.5% v/v, pH 3.2) and beer (7.0% v/v, pH 4.5) was compared with water, a nonalcoholic beverage of pH 3.2, and an ethanol solution (7.5% v/v, pH 7.6) using ambulatory pH measurement in healthy volunteers. The fraction of time at pH < 4 in the first hour after ingestion of 300 ml white wine (median 13.2%) was significantly increased compared with beer (3.6%; P < 0.01), water (0.9%; P < 0.001), ethanol (1.3%; P < 0.001), and the nonalcoholic beverage (0.9%; P < 0.05). Beer provoked significantly more gastroesophageal reflux than water (P < 0.01). It is concluded that white wine and beer induce gastroesophageal reflux, which is neither related to their ethanol content nor to their pH. The mechanism for this effect remains to be identified. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/8420765/Low_proof_alcoholic_beverages_and_gastroesophageal_reflux_ L2 - http://www.diseaseinfosearch.org/result/2996 DB - PRIME DP - Unbound Medicine ER -