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Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis.
J Clin Gastroenterol 1993; 16(1):16-21JC

Abstract

We have reviewed the clinical records of 226 consecutive adult patients with celiac sprue diagnosed in our department from 1972 to 1989. The study period has been divided into three subperiods of 6 years each (1972-1977, 1978-1983, 1984-1989). From the first to the third subperiod a significant increase in the number of new diagnoses and of the proportion of patients recognized by minor symptoms has been observed. These patients represent 50% of our series in the last 3 years of the study and 70% in 1989. Diagnosing subclinical forms of celiac sprue has significantly lowered the mean age at diagnosis and the female/male ratio. First-degree relatives of celiac patients; subjects who had a gluten-free diet for a period during childhood; patients with short stature, anemia, or amenorrhea of no obvious cause; or patients with unexplained immunological abnormalities are the groups in which most patients with subclinical celiac sprue have been found and in which potential patients should be sought. Helpful diagnostic tools include antigliadin antibody testing and the observation of absent or reduced Kerckring folds in the descending duodenum in the course of upper gastrointestinal endoscopy.

Authors+Show Affiliations

I Patologia Medica, Università di Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8421137

Citation

Corazza, G R., et al. "Subclinical Celiac Sprue. Increasing Occurrence and Clues to Its Diagnosis." Journal of Clinical Gastroenterology, vol. 16, no. 1, 1993, pp. 16-21.
Corazza GR, Frisoni M, Treggiari EA, et al. Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis. J Clin Gastroenterol. 1993;16(1):16-21.
Corazza, G. R., Frisoni, M., Treggiari, E. A., Valentini, R. A., Filipponi, C., Volta, U., & Gasbarrini, G. (1993). Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis. Journal of Clinical Gastroenterology, 16(1), pp. 16-21.
Corazza GR, et al. Subclinical Celiac Sprue. Increasing Occurrence and Clues to Its Diagnosis. J Clin Gastroenterol. 1993;16(1):16-21. PubMed PMID: 8421137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis. AU - Corazza,G R, AU - Frisoni,M, AU - Treggiari,E A, AU - Valentini,R A, AU - Filipponi,C, AU - Volta,U, AU - Gasbarrini,G, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 16 EP - 21 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 16 IS - 1 N2 - We have reviewed the clinical records of 226 consecutive adult patients with celiac sprue diagnosed in our department from 1972 to 1989. The study period has been divided into three subperiods of 6 years each (1972-1977, 1978-1983, 1984-1989). From the first to the third subperiod a significant increase in the number of new diagnoses and of the proportion of patients recognized by minor symptoms has been observed. These patients represent 50% of our series in the last 3 years of the study and 70% in 1989. Diagnosing subclinical forms of celiac sprue has significantly lowered the mean age at diagnosis and the female/male ratio. First-degree relatives of celiac patients; subjects who had a gluten-free diet for a period during childhood; patients with short stature, anemia, or amenorrhea of no obvious cause; or patients with unexplained immunological abnormalities are the groups in which most patients with subclinical celiac sprue have been found and in which potential patients should be sought. Helpful diagnostic tools include antigliadin antibody testing and the observation of absent or reduced Kerckring folds in the descending duodenum in the course of upper gastrointestinal endoscopy. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/8421137/Subclinical_celiac_sprue__Increasing_occurrence_and_clues_to_its_diagnosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8421137.ui DB - PRIME DP - Unbound Medicine ER -