Tags

Type your tag names separated by a space and hit enter

Efficacy of acellular pertussis vaccine in young infants.
J Infect Dis. 1993 Feb; 167(2):483-6.JI

Abstract

A prospective study of a pertussis outbreak in a residential facility was done. Among 19 residents aged < or = 2 years, 10 children were unimmunized and 9 were immunized with acellular pertussis vaccines. Of the 10 unimmunized children, 7 acquired laboratory-confirmed pertussis (four-fold titer rise, positive culture, or both); of these, 6 developed typical symptoms. Eight of the 9 immunized children acquired laboratory-confirmed infections, and 1 of these developed typical symptoms. No difference in infection was noted between the unimmunized and immunized groups (7/10 vs. 8/9, respectively), but a significant difference was observed in the development of symptoms (6/10 vs. 1/9, P < .05). Also, the isolation rate of Bordetella pertussis seemed to differ between the two groups (6/10 vs. 2/9, P = .12). In this population, acellular pertussis vaccine did not prevent infection with B. pertussis but protected most young infants from the onset of clinical symptoms.

Authors+Show Affiliations

Department of Pediatrics, Kawasaki Municipal Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8421187

Citation

Aoyama, T, et al. "Efficacy of Acellular Pertussis Vaccine in Young Infants." The Journal of Infectious Diseases, vol. 167, no. 2, 1993, pp. 483-6.
Aoyama T, Iwata T, Iwai H, et al. Efficacy of acellular pertussis vaccine in young infants. J Infect Dis. 1993;167(2):483-6.
Aoyama, T., Iwata, T., Iwai, H., Murase, Y., Saito, T., & Akamatsu, T. (1993). Efficacy of acellular pertussis vaccine in young infants. The Journal of Infectious Diseases, 167(2), 483-6.
Aoyama T, et al. Efficacy of Acellular Pertussis Vaccine in Young Infants. J Infect Dis. 1993;167(2):483-6. PubMed PMID: 8421187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of acellular pertussis vaccine in young infants. AU - Aoyama,T, AU - Iwata,T, AU - Iwai,H, AU - Murase,Y, AU - Saito,T, AU - Akamatsu,T, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 483 EP - 6 JF - The Journal of infectious diseases JO - J Infect Dis VL - 167 IS - 2 N2 - A prospective study of a pertussis outbreak in a residential facility was done. Among 19 residents aged < or = 2 years, 10 children were unimmunized and 9 were immunized with acellular pertussis vaccines. Of the 10 unimmunized children, 7 acquired laboratory-confirmed pertussis (four-fold titer rise, positive culture, or both); of these, 6 developed typical symptoms. Eight of the 9 immunized children acquired laboratory-confirmed infections, and 1 of these developed typical symptoms. No difference in infection was noted between the unimmunized and immunized groups (7/10 vs. 8/9, respectively), but a significant difference was observed in the development of symptoms (6/10 vs. 1/9, P < .05). Also, the isolation rate of Bordetella pertussis seemed to differ between the two groups (6/10 vs. 2/9, P = .12). In this population, acellular pertussis vaccine did not prevent infection with B. pertussis but protected most young infants from the onset of clinical symptoms. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/8421187/Efficacy_of_acellular_pertussis_vaccine_in_young_infants_ L2 - https://medlineplus.gov/tetanusdiphtheriaandpertussisvaccines.html DB - PRIME DP - Unbound Medicine ER -