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Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation.
JAMA. 1993 Feb 03; 269(5):593-7.JAMA

Abstract

OBJECTIVE

To examine the relationship between caffeine consumption during pregnancy and the occurrence of spontaneous abortion and intrauterine growth retardation.

DESIGN, SETTING, AND PATIENTS

A cohort of 431 women, enrolled in a multicenter study within 21 days of conception, was monitored throughout pregnancy to determine (1) caffeine exposure, (2) exposure to other risk factors, (3) fetal growth as assessed by ultrasonography, and (4) pregnancy outcome.

OUTCOME MEASURES

Spontaneous abortion, intrauterine growth, birth weight, and head circumference.

RESULTS

The mean (+/- SD) first-trimester caffeine consumption was not significantly higher in women who aborted (125.9 +/- 123.1 mg) than in women who delivered liveborn infants (111.6 +/- 107.0 mg) (P = 34). The adjusted odds ratio (OR) for spontaneous abortion was 1.15 (95% confidence interval [CI], 0.89 to 1.49). Early fetal growth, assessed by crown-rump length on ultrasonographic examination, was not affected by caffeine. Although the group consuming the most caffeine (> 300 mg/d) had a significantly higher proportion of babies with birth weights and head circumferences below the 10th percentile in the crude analysis, the association with caffeine was no longer significant when other risk factors (notably smoking) were taken into account. The adjusted ORs were 1.11 (95% CI, 0.88 to 1.40) for decreased birth weight and 1.09 (95% CI, 0.86 to 1.37) for smaller head circumference.

CONCLUSIONS

Close monitoring of a cohort identified very soon after conception enabled us to identify all abortions after 21 days postconception, monitor intrauterine growth prospectively, and track caffeine use. Despite this intensive surveillance, we found no evidence that moderate caffeine use increased the risk of spontaneous abortion, intrauterine growth retardation, or microcephaly after accounting for other risk factors.

Authors+Show Affiliations

Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

8421363

Citation

Mills, J L., et al. "Moderate Caffeine Use and the Risk of Spontaneous Abortion and Intrauterine Growth Retardation." JAMA, vol. 269, no. 5, 1993, pp. 593-7.
Mills JL, Holmes LB, Aarons JH, et al. Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. JAMA. 1993;269(5):593-7.
Mills, J. L., Holmes, L. B., Aarons, J. H., Simpson, J. L., Brown, Z. A., Jovanovic-Peterson, L. G., Conley, M. R., Graubard, B. I., Knopp, R. H., & Metzger, B. E. (1993). Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. JAMA, 269(5), 593-7.
Mills JL, et al. Moderate Caffeine Use and the Risk of Spontaneous Abortion and Intrauterine Growth Retardation. JAMA. 1993 Feb 3;269(5):593-7. PubMed PMID: 8421363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. AU - Mills,J L, AU - Holmes,L B, AU - Aarons,J H, AU - Simpson,J L, AU - Brown,Z A, AU - Jovanovic-Peterson,L G, AU - Conley,M R, AU - Graubard,B I, AU - Knopp,R H, AU - Metzger,B E, PY - 1993/2/3/pubmed PY - 1993/2/3/medline PY - 1993/2/3/entrez SP - 593 EP - 7 JF - JAMA JO - JAMA VL - 269 IS - 5 N2 - OBJECTIVE: To examine the relationship between caffeine consumption during pregnancy and the occurrence of spontaneous abortion and intrauterine growth retardation. DESIGN, SETTING, AND PATIENTS: A cohort of 431 women, enrolled in a multicenter study within 21 days of conception, was monitored throughout pregnancy to determine (1) caffeine exposure, (2) exposure to other risk factors, (3) fetal growth as assessed by ultrasonography, and (4) pregnancy outcome. OUTCOME MEASURES: Spontaneous abortion, intrauterine growth, birth weight, and head circumference. RESULTS: The mean (+/- SD) first-trimester caffeine consumption was not significantly higher in women who aborted (125.9 +/- 123.1 mg) than in women who delivered liveborn infants (111.6 +/- 107.0 mg) (P = 34). The adjusted odds ratio (OR) for spontaneous abortion was 1.15 (95% confidence interval [CI], 0.89 to 1.49). Early fetal growth, assessed by crown-rump length on ultrasonographic examination, was not affected by caffeine. Although the group consuming the most caffeine (> 300 mg/d) had a significantly higher proportion of babies with birth weights and head circumferences below the 10th percentile in the crude analysis, the association with caffeine was no longer significant when other risk factors (notably smoking) were taken into account. The adjusted ORs were 1.11 (95% CI, 0.88 to 1.40) for decreased birth weight and 1.09 (95% CI, 0.86 to 1.37) for smaller head circumference. CONCLUSIONS: Close monitoring of a cohort identified very soon after conception enabled us to identify all abortions after 21 days postconception, monitor intrauterine growth prospectively, and track caffeine use. Despite this intensive surveillance, we found no evidence that moderate caffeine use increased the risk of spontaneous abortion, intrauterine growth retardation, or microcephaly after accounting for other risk factors. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/8421363/Moderate_caffeine_use_and_the_risk_of_spontaneous_abortion_and_intrauterine_growth_retardation_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/269/pg/593 DB - PRIME DP - Unbound Medicine ER -