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Antral gastrin concentration in upper-gastrointestinal disease.
Am J Dig Dis. 1977 Mar; 22(3):201-8.AJ

Abstract

Antral gastrin concentration (AGC) was measured in prepyloric mucosa specimens obtained by forceps biopsy during endoscopic examination of 174 clinic and hospital patients. AGC in 32 patients who had normal endoscopic findings, the control group, varied widely from 2 to 38.6 ng gastrin/mg tissue. The mean AGC of the control patients was 14.2 +/- 1.4 (mean +/- 1 SE) ng gastrin/mg tissue. AGC was similar to control values in 18 patients with duodenal ulcer, 14.7 +/- 2.1; 12 patients with a pyloric channel or antral ulcer, 16.4 +/- 3.5; and 48 patients with miscellaneous diagnoses, 14.3 +/- 1.5. AGC was significantly less than control values in 13 patients with a ulcer in the body or fundus of the stomach, 5.9 +/- 1.5, and 4 patients with the Zollinger-Ellison syndrome, 4.9 +/- 2.4. AGC was significantly greater than in control values in 16 patients with gastritis, 25.8 +/- 4.3;22 patients with esophagitis, 23.2 +/- 3.0; and 9 patients with gastric atrophy and fasting serum hypergastrinemia 44.6 +/- 12.3. In group of 77 of these patients with heterogeneous diagnoses, meal-stimulated 3-hr integrated gastrin output was directly related to AGC (r = 0.47, P less than 0.001). In a group of 106 patients AGC was inversely related to histalogstimulated maximum acid output. The correlation was very weak (r = -0.20) but significant (P less than 0.05).

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

842527

Citation

Hughes, W S., et al. "Antral Gastrin Concentration in Upper-gastrointestinal Disease." The American Journal of Digestive Diseases, vol. 22, no. 3, 1977, pp. 201-8.
Hughes WS, Snyder N, Hernandez A. Antral gastrin concentration in upper-gastrointestinal disease. Am J Dig Dis. 1977;22(3):201-8.
Hughes, W. S., Snyder, N., & Hernandez, A. (1977). Antral gastrin concentration in upper-gastrointestinal disease. The American Journal of Digestive Diseases, 22(3), 201-8.
Hughes WS, Snyder N, Hernandez A. Antral Gastrin Concentration in Upper-gastrointestinal Disease. Am J Dig Dis. 1977;22(3):201-8. PubMed PMID: 842527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antral gastrin concentration in upper-gastrointestinal disease. AU - Hughes,W S, AU - Snyder,N, AU - Hernandez,A, PY - 1977/3/1/pubmed PY - 1977/3/1/medline PY - 1977/3/1/entrez SP - 201 EP - 8 JF - The American journal of digestive diseases JO - Am J Dig Dis VL - 22 IS - 3 N2 - Antral gastrin concentration (AGC) was measured in prepyloric mucosa specimens obtained by forceps biopsy during endoscopic examination of 174 clinic and hospital patients. AGC in 32 patients who had normal endoscopic findings, the control group, varied widely from 2 to 38.6 ng gastrin/mg tissue. The mean AGC of the control patients was 14.2 +/- 1.4 (mean +/- 1 SE) ng gastrin/mg tissue. AGC was similar to control values in 18 patients with duodenal ulcer, 14.7 +/- 2.1; 12 patients with a pyloric channel or antral ulcer, 16.4 +/- 3.5; and 48 patients with miscellaneous diagnoses, 14.3 +/- 1.5. AGC was significantly less than control values in 13 patients with a ulcer in the body or fundus of the stomach, 5.9 +/- 1.5, and 4 patients with the Zollinger-Ellison syndrome, 4.9 +/- 2.4. AGC was significantly greater than in control values in 16 patients with gastritis, 25.8 +/- 4.3;22 patients with esophagitis, 23.2 +/- 3.0; and 9 patients with gastric atrophy and fasting serum hypergastrinemia 44.6 +/- 12.3. In group of 77 of these patients with heterogeneous diagnoses, meal-stimulated 3-hr integrated gastrin output was directly related to AGC (r = 0.47, P less than 0.001). In a group of 106 patients AGC was inversely related to histalogstimulated maximum acid output. The correlation was very weak (r = -0.20) but significant (P less than 0.05). SN - 0002-9211 UR - https://www.unboundmedicine.com/medline/citation/842527/Antral_gastrin_concentration_in_upper_gastrointestinal_disease_ DB - PRIME DP - Unbound Medicine ER -