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Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes.
Free Radic Biol Med 1993; 14(2):139-47FR

Abstract

Sickle cell trait subjects are potentially at risk with microvascular complications frequently associated with high altitude and extreme exertion. Studies conducted in our laboratory suggest that exposure of sickle cell trait subjects to treadmill exercise resulted in an increase not only in the susceptibility of red blood cells to oxidation but also in the density of RBC membrane. The trend of increased susceptibility of red cells to oxidation as a consequence of exercise was associated with relatively excessive production of H2O2, inefficient breakdown of H2O2 by GSH-Px- and catalase-catalyzed reactions, and inability/failure to show a transitory increase in the activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating enzymes.

Authors+Show Affiliations

Department of Biochemistry, General Clinical Research Center, Meharry Medical College, Nashville, Tennessee 37208.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8425720

Citation

Das, S K., et al. "Effects of Physical Stress On Peroxide Scavengers in Normal and Sickle Cell Trait Erythrocytes." Free Radical Biology & Medicine, vol. 14, no. 2, 1993, pp. 139-47.
Das SK, Hinds JE, Hardy RE, et al. Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. Free Radic Biol Med. 1993;14(2):139-47.
Das, S. K., Hinds, J. E., Hardy, R. E., Collins, J. C., & Mukherjee, S. (1993). Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. Free Radical Biology & Medicine, 14(2), pp. 139-47.
Das SK, et al. Effects of Physical Stress On Peroxide Scavengers in Normal and Sickle Cell Trait Erythrocytes. Free Radic Biol Med. 1993;14(2):139-47. PubMed PMID: 8425720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. AU - Das,S K, AU - Hinds,J E, AU - Hardy,R E, AU - Collins,J C, AU - Mukherjee,S, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 139 EP - 47 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 14 IS - 2 N2 - Sickle cell trait subjects are potentially at risk with microvascular complications frequently associated with high altitude and extreme exertion. Studies conducted in our laboratory suggest that exposure of sickle cell trait subjects to treadmill exercise resulted in an increase not only in the susceptibility of red blood cells to oxidation but also in the density of RBC membrane. The trend of increased susceptibility of red cells to oxidation as a consequence of exercise was associated with relatively excessive production of H2O2, inefficient breakdown of H2O2 by GSH-Px- and catalase-catalyzed reactions, and inability/failure to show a transitory increase in the activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating enzymes. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/8425720/Effects_of_physical_stress_on_peroxide_scavengers_in_normal_and_sickle_cell_trait_erythrocytes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0891-5849(93)90004-E DB - PRIME DP - Unbound Medicine ER -