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Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes.

Abstract

Sickle cell trait subjects are potentially at risk with microvascular complications frequently associated with high altitude and extreme exertion. Studies conducted in our laboratory suggest that exposure of sickle cell trait subjects to treadmill exercise resulted in an increase not only in the susceptibility of red blood cells to oxidation but also in the density of RBC membrane. The trend of increased susceptibility of red cells to oxidation as a consequence of exercise was associated with relatively excessive production of H2O2, inefficient breakdown of H2O2 by GSH-Px- and catalase-catalyzed reactions, and inability/failure to show a transitory increase in the activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating enzymes.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, General Clinical Research Center, Meharry Medical College, Nashville, Tennessee 37208.

    , , ,

    Source

    Free radical biology & medicine 14:2 1993 Feb pg 139-47

    MeSH

    Adult
    African Continental Ancestry Group
    Catalase
    Erythrocyte Membrane
    Erythrocytes
    Exercise
    Free Radical Scavengers
    Glutathione Peroxidase
    Hemolysis
    Humans
    Hydrogen Peroxide
    Lipid Peroxidation
    Male
    NADP
    Oxidation-Reduction
    Sickle Cell Trait
    Stress, Physiological
    Superoxide Dismutase

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8425720

    Citation

    Das, S K., et al. "Effects of Physical Stress On Peroxide Scavengers in Normal and Sickle Cell Trait Erythrocytes." Free Radical Biology & Medicine, vol. 14, no. 2, 1993, pp. 139-47.
    Das SK, Hinds JE, Hardy RE, et al. Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. Free Radic Biol Med. 1993;14(2):139-47.
    Das, S. K., Hinds, J. E., Hardy, R. E., Collins, J. C., & Mukherjee, S. (1993). Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. Free Radical Biology & Medicine, 14(2), pp. 139-47.
    Das SK, et al. Effects of Physical Stress On Peroxide Scavengers in Normal and Sickle Cell Trait Erythrocytes. Free Radic Biol Med. 1993;14(2):139-47. PubMed PMID: 8425720.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. AU - Das,S K, AU - Hinds,J E, AU - Hardy,R E, AU - Collins,J C, AU - Mukherjee,S, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 139 EP - 47 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 14 IS - 2 N2 - Sickle cell trait subjects are potentially at risk with microvascular complications frequently associated with high altitude and extreme exertion. Studies conducted in our laboratory suggest that exposure of sickle cell trait subjects to treadmill exercise resulted in an increase not only in the susceptibility of red blood cells to oxidation but also in the density of RBC membrane. The trend of increased susceptibility of red cells to oxidation as a consequence of exercise was associated with relatively excessive production of H2O2, inefficient breakdown of H2O2 by GSH-Px- and catalase-catalyzed reactions, and inability/failure to show a transitory increase in the activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating enzymes. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/8425720/Effects_of_physical_stress_on_peroxide_scavengers_in_normal_and_sickle_cell_trait_erythrocytes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0891-5849(93)90004-E DB - PRIME DP - Unbound Medicine ER -