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Long-term impact of reproductive factors on cancer risk.
Int J Cancer 1993; 53(2):215-9IJ

Abstract

The relationship between reproductive variables (parity, age at first birth, number of induced and spontaneous abortions) and cancer risk has been analysed using data from an integrated series of case-control studies conducted in northern Italy between 1983 and 1992. The overall data-set included women below age 75 with histologically confirmed cancers of the following sites: oesophagus, 58; stomach, 280; colon, 405; rectum, 210; liver, 82; gall-bladder, 29; pancreas, 129; breast, 3,415; cervix, 742; endometrium, 725; ovary, 953; bladder, 68; kidney, 56; thyroid, 180; lymphomas, 80; myelomas, 57; and a total of 5,619 controls admitted to hospital for acute non-neoplastic, non-gynaecological, non-hormone-related conditions. Multivariate odds ratios, as estimators of relative risks (RR), were obtained after allowance for age, education, use of oral contraceptives and oestrogen replacement treatments, plus various reproductive factors. Direct significant trends with parity were observed for cancer of the liver (RR for women with > or = 4 births vs. nulliparae = 3.3) and cervix uteri (RR = 4.1). The risk of gall-bladder cancer was also elevated for multiparae (RR = 1.9). No significant inverse trend in risk emerged. However, the RRs in multiparae were significantly below unity for breast (RR = 0.8), endometrium (RR = 0.7), and ovary (RR = 0.8). With reference to age at first birth, a significant trend in risk was observed for breast cancer (RR = 1.4 for 25 to 29 and 1.5 for > or = 30 vs. < 25 years). In contrast, the risk of cervical cancer was inversely related to age at first birth. For spontaneous abortions, the only significant inverse trend was for ovarian cancer (RR = 0.7 for > or = 2 vs. 0 abortions), but also the point estimate for endometrial cancer in women with > or = 2 abortions was below unity. For induced abortions, there was a strong inverse trend in risk for endometrial cancer (RR = 0.5), and the RRs were below unity also for colon and breast cancer. In contrast, cervical cancer was directly associated with the number of spontaneous abortions. Although the underlying aetiological interpretations are different for various cancer sites, this study provides, in a large and uniform data-set, quantitative information on the long-term impact of reproductive factors on cancer risk.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8425757

Citation

La Vecchia, C, et al. "Long-term Impact of Reproductive Factors On Cancer Risk." International Journal of Cancer, vol. 53, no. 2, 1993, pp. 215-9.
La Vecchia C, Negri E, Franceschi S, et al. Long-term impact of reproductive factors on cancer risk. Int J Cancer. 1993;53(2):215-9.
La Vecchia, C., Negri, E., Franceschi, S., & Parazzini, F. (1993). Long-term impact of reproductive factors on cancer risk. International Journal of Cancer, 53(2), pp. 215-9.
La Vecchia C, et al. Long-term Impact of Reproductive Factors On Cancer Risk. Int J Cancer. 1993 Jan 21;53(2):215-9. PubMed PMID: 8425757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term impact of reproductive factors on cancer risk. AU - La Vecchia,C, AU - Negri,E, AU - Franceschi,S, AU - Parazzini,F, PY - 1993/1/21/pubmed PY - 1993/1/21/medline PY - 1993/1/21/entrez KW - Abortion, Induced KW - Abortion, Spontaneous KW - Age Factors KW - Biology KW - Cancer KW - Case Control Studies KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Fertility KW - Fertility Control, Postconception KW - Fertility Measurements KW - Italy KW - Longterm Effects KW - Maternal Age KW - Mediterranean Countries KW - Neoplasms KW - Parental Age KW - Parity KW - Population KW - Population Characteristics KW - Population Dynamics KW - Pregnancy Complications KW - Research Methodology KW - Research Report KW - Risk Factors KW - Southern Europe KW - Studies KW - Time Factors SP - 215 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 53 IS - 2 N2 - The relationship between reproductive variables (parity, age at first birth, number of induced and spontaneous abortions) and cancer risk has been analysed using data from an integrated series of case-control studies conducted in northern Italy between 1983 and 1992. The overall data-set included women below age 75 with histologically confirmed cancers of the following sites: oesophagus, 58; stomach, 280; colon, 405; rectum, 210; liver, 82; gall-bladder, 29; pancreas, 129; breast, 3,415; cervix, 742; endometrium, 725; ovary, 953; bladder, 68; kidney, 56; thyroid, 180; lymphomas, 80; myelomas, 57; and a total of 5,619 controls admitted to hospital for acute non-neoplastic, non-gynaecological, non-hormone-related conditions. Multivariate odds ratios, as estimators of relative risks (RR), were obtained after allowance for age, education, use of oral contraceptives and oestrogen replacement treatments, plus various reproductive factors. Direct significant trends with parity were observed for cancer of the liver (RR for women with > or = 4 births vs. nulliparae = 3.3) and cervix uteri (RR = 4.1). The risk of gall-bladder cancer was also elevated for multiparae (RR = 1.9). No significant inverse trend in risk emerged. However, the RRs in multiparae were significantly below unity for breast (RR = 0.8), endometrium (RR = 0.7), and ovary (RR = 0.8). With reference to age at first birth, a significant trend in risk was observed for breast cancer (RR = 1.4 for 25 to 29 and 1.5 for > or = 30 vs. < 25 years). In contrast, the risk of cervical cancer was inversely related to age at first birth. For spontaneous abortions, the only significant inverse trend was for ovarian cancer (RR = 0.7 for > or = 2 vs. 0 abortions), but also the point estimate for endometrial cancer in women with > or = 2 abortions was below unity. For induced abortions, there was a strong inverse trend in risk for endometrial cancer (RR = 0.5), and the RRs were below unity also for colon and breast cancer. In contrast, cervical cancer was directly associated with the number of spontaneous abortions. Although the underlying aetiological interpretations are different for various cancer sites, this study provides, in a large and uniform data-set, quantitative information on the long-term impact of reproductive factors on cancer risk. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/8425757/Long_term_impact_of_reproductive_factors_on_cancer_risk_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0020-7136&amp;date=1993&amp;volume=53&amp;issue=2&amp;spage=215 DB - PRIME DP - Unbound Medicine ER -