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Autoeczematization is associated with abnormal immune recognition of autologous skin antigens.
J Am Acad Dermatol. 1993 Jan; 28(1):56-60.JA

Abstract

BACKGROUND

The pathogenesis of autoeczematization (AE) is not well understood; however, previous studies suggest that AE is an autoimmune condition.

OBJECTIVE

Our purpose was to assess whether AE is associated with an abnormal immune recognition of autologous skin antigens.

METHODS

Eight patients with AE, six healthy control subjects, and three patients with localized contact dermatitis (LCD) were studied. Activation markers were detected on peripheral blood T lymphocytes. Autologous mixed epidermal cell-lymphocyte reaction (AMECLR) was performed for each subject and cell proliferation was assessed by tritiated thymidine incorporation.

RESULTS

Many activated T cells were detected in patients with AE (5.2% +/- 4.5% vs 0.2% +/- 0.4% in control subjects, p < 0.05). AMECLR showed a significantly higher cell proliferation in AE compared with both healthy subjects and patients with LCD (6372 +/- 3217 cpm vs 2638 +/- 1788 cpm, and 2471 +/- 1389 cpm, respectively; p < 0.05). Peripheral blood mononuclear cells cultured in the presence of an autologous skin homogenate also showed a significantly increased cell proliferation in patients with AE than in control subjects.

CONCLUSION

Our results suggest that an abnormal immune response against autologous skin antigens occurs in AE that could be related to the pathogenesis of this disease.

Authors+Show Affiliations

Department of Immunology, School of Medicine, University of San Luis Potosi, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8425971

Citation

González-Amaro, R, et al. "Autoeczematization Is Associated With Abnormal Immune Recognition of Autologous Skin Antigens." Journal of the American Academy of Dermatology, vol. 28, no. 1, 1993, pp. 56-60.
González-Amaro R, Baranda L, Abud-Mendoza C, et al. Autoeczematization is associated with abnormal immune recognition of autologous skin antigens. J Am Acad Dermatol. 1993;28(1):56-60.
González-Amaro, R., Baranda, L., Abud-Mendoza, C., Delgado, S. P., & Moncada, B. (1993). Autoeczematization is associated with abnormal immune recognition of autologous skin antigens. Journal of the American Academy of Dermatology, 28(1), 56-60.
González-Amaro R, et al. Autoeczematization Is Associated With Abnormal Immune Recognition of Autologous Skin Antigens. J Am Acad Dermatol. 1993;28(1):56-60. PubMed PMID: 8425971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoeczematization is associated with abnormal immune recognition of autologous skin antigens. AU - González-Amaro,R, AU - Baranda,L, AU - Abud-Mendoza,C, AU - Delgado,S P, AU - Moncada,B, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 56 EP - 60 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 28 IS - 1 N2 - BACKGROUND: The pathogenesis of autoeczematization (AE) is not well understood; however, previous studies suggest that AE is an autoimmune condition. OBJECTIVE: Our purpose was to assess whether AE is associated with an abnormal immune recognition of autologous skin antigens. METHODS: Eight patients with AE, six healthy control subjects, and three patients with localized contact dermatitis (LCD) were studied. Activation markers were detected on peripheral blood T lymphocytes. Autologous mixed epidermal cell-lymphocyte reaction (AMECLR) was performed for each subject and cell proliferation was assessed by tritiated thymidine incorporation. RESULTS: Many activated T cells were detected in patients with AE (5.2% +/- 4.5% vs 0.2% +/- 0.4% in control subjects, p < 0.05). AMECLR showed a significantly higher cell proliferation in AE compared with both healthy subjects and patients with LCD (6372 +/- 3217 cpm vs 2638 +/- 1788 cpm, and 2471 +/- 1389 cpm, respectively; p < 0.05). Peripheral blood mononuclear cells cultured in the presence of an autologous skin homogenate also showed a significantly increased cell proliferation in patients with AE than in control subjects. CONCLUSION: Our results suggest that an abnormal immune response against autologous skin antigens occurs in AE that could be related to the pathogenesis of this disease. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/8425971/Autoeczematization_is_associated_with_abnormal_immune_recognition_of_autologous_skin_antigens L2 - https://linkinghub.elsevier.com/retrieve/pii/0190-9622(93)70009-I DB - PRIME DP - Unbound Medicine ER -