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Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats.
Am J Clin Nutr 1993; 57(2 Suppl):240S-243SAJ

Abstract

This paper compares the effects of combined iodine and selenium deficiency, of single deficiencies of these trace elements, and of no deficiency on thyroid hormone metabolism in rats. In rats deficient in both trace elements, thyroidal triiodothyronine (T3), thyroidal thyroxin (T4), thyroidal total iodine, hepatic T4, and plasma T4 were significantly lower, and plasma thyroid-stimulating hormone (TSH) and thyroid weight were significantly higher than in rats deficient in iodine alone. Plasma and hepatic T3 concentrations were similar in the dietary groups. Hepatic type I iodothyronine deiodinase (ID-I) activity was inhibited by selenium deficiency irrespective of the iodine status. Type II deiodinase (ID-II) activity in the brain was significantly higher and in pituitary, significantly lower in combined deficiency than in iodine deficiency alone. These data show that selenium can play an important role in determining the severity of the hypothyroidism associated with iodine deficiency.

Authors+Show Affiliations

University Department of Clinical Chemistry, Royal Infirmary, Edinburgh, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8427196

Citation

Beckett, G J., et al. "Effects of Combined Iodine and Selenium Deficiency On Thyroid Hormone Metabolism in Rats." The American Journal of Clinical Nutrition, vol. 57, no. 2 Suppl, 1993, 240S-243S.
Beckett GJ, Nicol F, Rae PW, et al. Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats. Am J Clin Nutr. 1993;57(2 Suppl):240S-243S.
Beckett, G. J., Nicol, F., Rae, P. W., Beech, S., Guo, Y., & Arthur, J. R. (1993). Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats. The American Journal of Clinical Nutrition, 57(2 Suppl), 240S-243S. doi:10.1093/ajcn/57.2.240S.
Beckett GJ, et al. Effects of Combined Iodine and Selenium Deficiency On Thyroid Hormone Metabolism in Rats. Am J Clin Nutr. 1993;57(2 Suppl):240S-243S. PubMed PMID: 8427196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats. AU - Beckett,G J, AU - Nicol,F, AU - Rae,P W, AU - Beech,S, AU - Guo,Y, AU - Arthur,J R, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 240S EP - 243S JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 57 IS - 2 Suppl N2 - This paper compares the effects of combined iodine and selenium deficiency, of single deficiencies of these trace elements, and of no deficiency on thyroid hormone metabolism in rats. In rats deficient in both trace elements, thyroidal triiodothyronine (T3), thyroidal thyroxin (T4), thyroidal total iodine, hepatic T4, and plasma T4 were significantly lower, and plasma thyroid-stimulating hormone (TSH) and thyroid weight were significantly higher than in rats deficient in iodine alone. Plasma and hepatic T3 concentrations were similar in the dietary groups. Hepatic type I iodothyronine deiodinase (ID-I) activity was inhibited by selenium deficiency irrespective of the iodine status. Type II deiodinase (ID-II) activity in the brain was significantly higher and in pituitary, significantly lower in combined deficiency than in iodine deficiency alone. These data show that selenium can play an important role in determining the severity of the hypothyroidism associated with iodine deficiency. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/8427196/Effects_of_combined_iodine_and_selenium_deficiency_on_thyroid_hormone_metabolism_in_rats_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/57.2.240S DB - PRIME DP - Unbound Medicine ER -