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Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs.
J Am Vet Med Assoc. 1993 Jan 15; 202(2):251-6.JA

Abstract

A randomized, double-blind, controlled study was performed with 18 arthritic dogs administered aspirin (25 mg/kg of body weight, PO, q 8 h) and excipient (control group) or aspirin and misoprostol (100 micrograms, PO, q 8 h). Dogs in the misoprostol (n = 10) and control (n = 8) groups were primarily compared by use of sequential gastroduodenoscopy, changes in PCV, and prevalence of clinical signs of gastrointestinal disturbance over a 14-day treatment period. The misoprostol/aspirin-treated group had significantly (P < 0.05) less gastroduodenal hemorrhage and ulceration and a significantly (P < 0.05) lower prevalence of vomiting than did the control group.

Authors+Show Affiliations

Murtaugh RJ
Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
Matz ME
No affiliation info available
Labato MA
No affiliation info available
Boudrieau RJ
No affiliation info available

MeSH

AnimalsAspirinDiarrheaDog DiseasesDogsDouble-Blind MethodDuodenoscopyFemaleGastrointestinal HemorrhageGastroscopyMaleMisoprostolOsteoarthritisPeptic UlcerVomiting

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8428830

Citation

Murtaugh, R J., et al. "Use of Synthetic Prostaglandin E1 (misoprostol) for Prevention of Aspirin-induced Gastroduodenal Ulceration in Arthritic Dogs." Journal of the American Veterinary Medical Association, vol. 202, no. 2, 1993, pp. 251-6.
Murtaugh RJ, Matz ME, Labato MA, et al. Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs. J Am Vet Med Assoc. 1993;202(2):251-6.
Murtaugh, R. J., Matz, M. E., Labato, M. A., & Boudrieau, R. J. (1993). Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs. Journal of the American Veterinary Medical Association, 202(2), 251-6.
Murtaugh RJ, et al. Use of Synthetic Prostaglandin E1 (misoprostol) for Prevention of Aspirin-induced Gastroduodenal Ulceration in Arthritic Dogs. J Am Vet Med Assoc. 1993 Jan 15;202(2):251-6. PubMed PMID: 8428830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs. AU - Murtaugh,R J, AU - Matz,M E, AU - Labato,M A, AU - Boudrieau,R J, PY - 1993/1/15/pubmed PY - 1993/1/15/medline PY - 1993/1/15/entrez SP - 251 EP - 6 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 202 IS - 2 N2 - A randomized, double-blind, controlled study was performed with 18 arthritic dogs administered aspirin (25 mg/kg of body weight, PO, q 8 h) and excipient (control group) or aspirin and misoprostol (100 micrograms, PO, q 8 h). Dogs in the misoprostol (n = 10) and control (n = 8) groups were primarily compared by use of sequential gastroduodenoscopy, changes in PCV, and prevalence of clinical signs of gastrointestinal disturbance over a 14-day treatment period. The misoprostol/aspirin-treated group had significantly (P < 0.05) less gastroduodenal hemorrhage and ulceration and a significantly (P < 0.05) lower prevalence of vomiting than did the control group. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/8428830/Use_of_synthetic_prostaglandin_E1__misoprostol__for_prevention_of_aspirin_induced_gastroduodenal_ulceration_in_arthritic_dogs_ L2 - https://medlineplus.gov/pepticulcer.html DB - PRIME DP - Unbound Medicine ER -