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Antibody response to outer membrane protein of nontypeable Haemophilus influenzae in otitis-prone children.
J Pediatr. 1993 Feb; 122(2):212-8.JPed

Abstract

One of the major outer membrane proteins of nontypeable Haemophilus influenzae, P6, is highly conserved among strains, serves as a target for bactericidal antibody, and has been proposed as a possible vaccine candidate. The serum antibody response to P6 was studied in otitis-prone and normal children by an enzyme-linked immunosorbent assay. Of 20 otitis-prone children, 12 (60%) had a serum IgG antibody response to P6 after otitis media; however, the mean acute antibody level for the group, 4.6 micrograms/ml, was not significantly different from the convalescent level, 5.4 micrograms/ml. Anti-P6 antibody levels were also measured longitudinally for 10 to 25 months in 30 otitis-prone and 13 healthy children. Antibody levels increased sevenfold in the normal group compared with less than three-fold for the otitis-prone group and were significantly higher in the normal children after the age of 18 months (p < 0.05). Finally, otitis-prone children who had two or more episodes of otitis media with nontypeable H. influenzae did not have an anamnestic antibody response to P6. The failure to recognize P6 as a specific immunogen may account for recurrent infections. Moreover, the data suggest that otitis-prone children may not respond adequately to a vaccine containing P6.

Authors+Show Affiliations

Department of Otolaryngology, Sapporo Medical College, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8429433

Citation

Yamanaka, N, and H Faden. "Antibody Response to Outer Membrane Protein of Nontypeable Haemophilus Influenzae in Otitis-prone Children." The Journal of Pediatrics, vol. 122, no. 2, 1993, pp. 212-8.
Yamanaka N, Faden H. Antibody response to outer membrane protein of nontypeable Haemophilus influenzae in otitis-prone children. J Pediatr. 1993;122(2):212-8.
Yamanaka, N., & Faden, H. (1993). Antibody response to outer membrane protein of nontypeable Haemophilus influenzae in otitis-prone children. The Journal of Pediatrics, 122(2), 212-8.
Yamanaka N, Faden H. Antibody Response to Outer Membrane Protein of Nontypeable Haemophilus Influenzae in Otitis-prone Children. J Pediatr. 1993;122(2):212-8. PubMed PMID: 8429433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody response to outer membrane protein of nontypeable Haemophilus influenzae in otitis-prone children. AU - Yamanaka,N, AU - Faden,H, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 212 EP - 8 JF - The Journal of pediatrics JO - J Pediatr VL - 122 IS - 2 N2 - One of the major outer membrane proteins of nontypeable Haemophilus influenzae, P6, is highly conserved among strains, serves as a target for bactericidal antibody, and has been proposed as a possible vaccine candidate. The serum antibody response to P6 was studied in otitis-prone and normal children by an enzyme-linked immunosorbent assay. Of 20 otitis-prone children, 12 (60%) had a serum IgG antibody response to P6 after otitis media; however, the mean acute antibody level for the group, 4.6 micrograms/ml, was not significantly different from the convalescent level, 5.4 micrograms/ml. Anti-P6 antibody levels were also measured longitudinally for 10 to 25 months in 30 otitis-prone and 13 healthy children. Antibody levels increased sevenfold in the normal group compared with less than three-fold for the otitis-prone group and were significantly higher in the normal children after the age of 18 months (p < 0.05). Finally, otitis-prone children who had two or more episodes of otitis media with nontypeable H. influenzae did not have an anamnestic antibody response to P6. The failure to recognize P6 as a specific immunogen may account for recurrent infections. Moreover, the data suggest that otitis-prone children may not respond adequately to a vaccine containing P6. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/8429433/Antibody_response_to_outer_membrane_protein_of_nontypeable_Haemophilus_influenzae_in_otitis_prone_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(06)80115-0 DB - PRIME DP - Unbound Medicine ER -